Catalytic asymmetric fluorinations
Catalytic asymmetric fluorinations
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DOI：
10.1039/b603163c
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发表时间：
2006-01-01
影响因子：
3.2
通讯作者：
Gouverneur, Veronique
中科院分区：
文献类型：
--
作者：
Bobbio, Carla;Gouverneur, Veronique
具有广泛反应活性的结构多样性氟化试剂的出现对于迄今为止已知的催化不对称氟化工艺的发展至关重要。在这篇文章中，我们将讨论这一领域的研究是如何出现的，以及哪些策略使得亲核和亲电催化对映选择性氟化反应得以成功发展。我们还提出了最有效的工艺的催化活性和对映体选择性的基本理解，并强调了第一个合成应用与复杂的氟化目标的制备。
The appearance of structurally diverse fluorinating reagents displaying a large spectrum of reactivity has been critical to the development of the catalytic asymmetric fluorination processes known to date. In this article, we discuss how this area of research emerged and which strategies have allowed for the successful development of both nucleophilic and electrophilic catalytic enantioselective fluorinations. We also present the fundamental understanding of catalytic activity and enantioselectivity for the most efficient processes and highlight the first synthetic application with the preparation of a complex fluorinated target.