INHERITANCE AND REGRESSION TOWARD THE MEAN IN HETEROGENEOUS CELL-POPULATIONS
INHERITANCE AND REGRESSION TOWARD THE MEAN IN HETEROGENEOUS CELL-POPULATIONS
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DOI：
10.1111/j.1365-2184.1991.tb01157.x
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发表时间：
1991-05-01
影响因子：
8.5
通讯作者：
AXELROD, DE
中科院分区：
文献类型：
--
作者：
GAMEL, JW;AXELROD, DE
甚至在相同环境中增殖的相同细胞的非突变后代之间，诸如出生大小和寿命的性状也可能差异很大。 另一方面，这些性状的群体参数可能在多代中保持稳定，并且这些性状可能从母亲到女儿有明显的遗传。 我们已经重新考虑的含义，母亲和女儿的相关性，在线性回归分析。 有人提出，一个非突变的细胞，其表型偏离人口的平均值产生的后代，其回归率的平均值是成比例的1-r，其中r是母亲的女儿相关系数的性状正在研究。 这一命题的理论支持来自线性回归分析。 在NIH 3 T3小鼠成纤维细胞中细胞生长常数的谱系分析中发现了经验支持，其中活化的人ras癌基因的存在与后代生长常数向群体平均值回归的降低的r和增加的速率相关。
Traits such as birth size and lifetime can vary widely even among non-mutated progeny of the same cell proliferating in the same environment. On the other hand, population parameters of these traits may remain stable over many generations, and there may be a distinct inheritance of these traits from mother to daughters. We have reconsidered the implication of mother-daughter correlations in light of linear regression analysis. It is proposed that a non-mutant cell whose phenotype deviates from the population mean produces progeny whose rate of regression toward the mean is proportional to 1-r, where r is the mother-daughter correlation coefficient of the trait under study. Theoretical support for this proposition is derived from linear regression analysis. Empirical support is found in pedigree analysis of cell growth constants among NIH3T3 mouse fibroblast cells, where the presence of an activated human ras oncogene is associated with a decreased r and an increased rate at which the growth constants of progeny regress toward the population mean.