Subfield-specific tractography of the hippocampus in epilepsy patients at 7 Tesla.
Subfield-specific tractography of the hippocampus in epilepsy patients at 7 Tesla.
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7特斯拉的癫痫患者的海马的子场特异性拖拉学。
DOI：
10.1016/j.seizure.2018.09.005
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Balchandani P
中科院分区：
文献类型：
--
作者：
Rutland JW;Feldman RE;Delman BN;Panov F;Fields MC;Marcuse LV;Hof PR;Lin HM;Balchandani P
mri阴性癫痫患者可以受益于先进的成像技术，如高分辨率扩散磁共振成像（dMRI）。我们的目的是在mri阴性患者中进行海马亚区特异性牵道造影并量化亚区连通性。海马亚区异常连通性可能有助于证实癫痫病灶假说，并为指导手术干预提供信息。对25例耐药mri阴性患者和25例健康志愿者进行海马结构成像和dMRI。在高分辨率结构图像上对每个受试者的海马进行分割，并在每个子区进行基于dmri的概率神经束成像。对癫痫患者和健康志愿者海马亚区连通性程度和纤维密度进行量化比较。我们能够对参与这项研究的每个受试者进行亚场特异性海马束造影。这些方法确定了mri阴性患者的一些海马亚区异常连接。特别是疑似左侧颞叶癫痫灶的患者，表现出某些同侧亚场的连通性增加，特别是耻骨下、耻骨前和耻骨旁，而一些对侧亚场的连通性降低，如CA1和耻骨下。我们的数据表明，在不同类型的癫痫中，海马体子区以不同的方式连接。这些结果可能提供重要的信息，可以帮助告知癫痫病灶假说和mri阴性患者的手术治疗。这些观察结果表明，基于dmri的高分辨率海马亚区造影可以在mri阴性的患者中发现细微的异常。
MRI-negative epilepsy patients could benefit from advanced imaging techniques such as high-resolution diffusion magnetic resonance imaging (dMRI). Our aim was to perform hippocampal subfield-specific tractography and quantify connectivity of the subfields in MRI-negative patients. Abnormal connectivity of the hippocampal subfields may help inform seizure focus hypothesis and provide information to guide surgical intervention. Hippocampal structural imaging and dMRI was acquired in 25 drug resistant MRI-negative patients and 25 healthy volunteers. The hippocampi of each subject was segmented on high-resolution structural images and dMRI-based probabilistic tractography was performed in each subfield. The degrees of connectivity and fiber densities of the hippocampal subfields were quantified and compared between epilepsy patients and healthy volunteers. We were able to perform subfield-specific hippocampal tractography in each subject that participated in this study. These methods identified some hippocampal subfields that are abnormally connected in MRI-negative patients. In particular patients suspected of left temporal seizure focus exhibited increased connectivity of certain ipsilateral subfields, especially the subiculum, presubiculum, and parasubiculum, and reduced connectivity of some contralateral subfields, such as CA1 and subiculum. Our data suggest that the hippocampal subfields are connected in distinct ways in different types of epilepsy. These results may provide important information that could help inform seizure focus hypothesis and in the surgical treatment of MRI-negative patients. These observations suggest that high-resolution dMRI-based tractography of the hippocampal subfields can detect subtle abnormalities in otherwise normal-appearing MRI-negative patients.
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