Impact of adherence and highly active antiretroviral therapy on survival in HIV-infected patients
Impact of adherence and highly active antiretroviral therapy on survival in HIV-infected patients
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DOI：
10.1097/00042560-200205010-00014
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发表时间：
2002-05-01
期刊：
影响因子：
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通讯作者：
Caylà, JA
中科院分区：
文献类型：
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作者：
de Olalla, PG;Knobel, H;Caylà, JA
目的：为了评估抗逆转录病毒治疗（ART）坚持对HIV感染patients.Design生存的影响：队列研究在一家医院在Barcelona，Spains.Methods：数据对HIV感染患者年龄大于18岁的开始ART在1990年至1999年期间进行了分析。如果抗逆转录病毒药物的总剂量低于处方的90%，则认为患者未依从。通过自我报告和医院药房预约评估依从性。结果：共纳入1219例患者，采用考克斯回归分析。第一次抗逆转录病毒治疗是23.7%的病例采用单药治疗，30.5%采用两种药物治疗，45.8%采用三联治疗。在多变量分析中，与死亡率有显著差异的变量是治疗开始时的临床分期（AIDS：相对危险度（RH）2.97; 95%置信区间[Cl]：2.14-4.13）、CD 4细胞计数（
Objectives: To assess the effect of antiretroviral therapy (ART) adherence on survival in HIV-infected patients.Design: Cohort study at a single hospital in Barcelona, Spain.Methods: Data on HIV-infected patients older than 18 years of age who began ART during the period 1990 to 1999 were analyzed. Patients were considered nonadherent if the total dose of antiretroviral drug was less than 90% of that prescribed. Adherence was assessed through self-report and hospital pharmacy appointments. Cox regression with time-dependent variables was used.Results: A total of 1219 patients were included. The first ART was with monotherapy in 23.7% of cases, with two drugs in 30.5%, and with triple therapy in 45.8%. In multivariate analysis, the variables that presented significant differences with respect to mortality were clinical stage at the beginning of treatment (AIDS: relative hazard (RH) 2.97; 95% confidence interval [Cl]: 2.14-4.13), CD4 cell count (