Vascular factors in dementia: an overview
Vascular factors in dementia: an overview
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DOI：
10.1016/j.jns.2004.09.005
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发表时间：
2004-11-15
影响因子：
4.4
通讯作者：
DeCarli, C
中科院分区：
文献类型：
--
作者：
DeCarli, C
老年痴呆症和脑血管病是老年人常见的两种疾病。传统观点试图分别描述和治疗这两种疾病。然而，越来越多的证据表明，脑血管危险因素可能导致无症状的脑损伤，与阿尔茨海默病共享遗传风险，并可能加速阿尔茨海默病的进程。这些证据表明，这两种疾病可能会叠加或协同作用，导致临床痴呆症。这篇评论的重点是不断变化的数据，支持这一假设。(C)2004 Elsevier B.V.保留所有权利。
Alzheimer's disease and cerebrovascular disease are two illnesses common to the elderly. Conventional wisdom has sought to separately describe and treat these two diseases. Accumulating evidence, however, shows that cerebrovascular risk factors may cause asymptomatic brain injury, share genetic risk with Alzheimer's disease and possibly accelerate the Alzheimer's process. Such evidence suggests that these two diseases may act additively or synergistically to cause clinical dementia. This review focuses on evolving data that support this hypothesis. (C) 2004 Elsevier B.V. All rights reserved.