Effect of male age on fertility: evidence for the decline in male fertility with increasing age
Effect of male age on fertility: evidence for the decline in male fertility with increasing age
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DOI：
10.1016/s0015-0282(03)00366-2
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发表时间：
2003-06-01
影响因子：
6.7
通讯作者：
Killick, SR
中科院分区：
文献类型：
--
作者：
Hassan, MAM;Killick, SR
目的：利用尝试怀孕时的年龄，调整女性年龄、性交频率和生活方式特征的混杂影响，评估男性年龄对怀孕时间 (TTP) 的影响。设计：观察性研究。地点：英国赫尔的教学医院。患者：2112 连续怀孕妇女。干预措施：一份询问 TTP、避孕药具使用、怀孕计划、既往史的问卷调查。生育力低下、既往怀孕情况、年龄和双方的个人生活方式特征。主要结果指标：怀孕缴费、受孕率以及男性和女性年龄组生育力低下的相对风险。结果：与女性年龄一样，男性年龄的增加与 TTP 显着上升和受孕率下降相关。男性年龄 >45 岁时，TTP 增加五倍。相对于男性，45 岁的 TTP >1 或 >2 年的可能性分别高出 4.6 倍和 12.5 倍。将分析仅限于年轻女性的伴侣，结果发现男性年龄增长也有类似的影响。 35 岁以上女性生育能力低下的可能性是女性的 2.2 倍
Objective: To evaluate the effect of men's age on time to pregnancy (TTP) using age at the onset of pregnancy attempts, adjusting for the confounding effects of women's age, coital frequency, and life-style characteristics.Design: Observational study.Setting: Teaching hospital in Hull, United Kingdom.Patient(s): Two thousand one hundred twelve consecutive pregnant women.Intervention(s): A questionnaire inquiring about TTP, contraceptive use, pregnancy planning, previous subfertility, previous pregnancies, age, and individual life-style characteristics of both partners.Main Outcome Measure(s): Tithe to pregnancy, conception rates, and relative risk of subfecundity for men and women's age groups.Result(s): As with women's age, increasing men's age was associated with significantly rising TTP and declining conception rates. A fivefold increase in TTP occurred with men's age >45 years. Relative to men 45 years were 4.6-fold and 12.5-fold more likely to have had TTP of >1 or >2 years. Restricting the analysis to partners of young women revealed similar effects of increasing men's age. Women >35 years were 2.2-fold more likely to be subfertile than women