Matrix-associated autologous chondrocyte transplantation/implantation (MACT/MACI) - 5-year follow-up
Matrix-associated autologous chondrocyte transplantation/implantation (MACT/MACI) - 5-year follow-up
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DOI：
10.1016/j.knee.2006.02.012
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发表时间：
2006-06-01
期刊：
影响因子：
1.9
通讯作者：
Russlies, Martin
中科院分区：
文献类型：
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作者：
Behrens, Peter;Bitter, Thomas;Russlies, Martin
基质相关自体软骨细胞移植/植入（Matrix-associated autologous软骨细胞transplantation/implantation，MACT/MACI）是一种新的手术方法，使用细胞接种的胶原基质修复局部全层软骨缺损。进行了前瞻性的临床调查，以澄清这是否证明是合适的，并确认客观和主观的临床改善，在一段长达5年的手术后。38例局部软骨缺损的患者进行了治疗与MACT。在临床随访的背景下，这些患者在干预后进行了长达5年的评估。四种不同的评分（Meyers评分，Tegner-Lysholm活动评分，Lysholm-Giliquist评分，ICRS评分）以及从四名患者中获得的六次关节镜检查和活检结果构成了本研究的基础。对于15例患者，在本研究完成时，自手术以来已过去5年或更长时间。这15例患者中有11例（73.3%）可以获得术后5年的结果。总的来说，我们纳入了25例术后2年或更长时间的患者进行评估。11例患者中有8例在移植后5年评价膝关节功能明显改善或优于术前。与术前值相比，4项评分中有3项显示出显著改善。一个评分，Tegner-Lysholm评分显示改善，然而，这并不显着，5年后三个评分的显着改善结果表明，MACT是一个合适的，但成本密集的替代治疗局部软骨缺损的膝盖。(C)2006 Elsevier B. V.保留所有权利。
Matrix-associated autologous chondrocyte transplantation/implantation (MACT/MACI) is a new operation procedure using a cell seeded collagen matrix for the treatement of localized full-thickness cartilage defects. A prospective clinical investigation was carried out in order to clarify whether this proves suitable and confirms objective and subjective clinical improvement over a period of up to 5 years after operation.Thirty-eight patients with localised cartilage defects were treated with MACT. Within the context of clinical follow-up, these patients were evaluated for up to 5 years after the intervention. Four different scores (Meyers score, Tegner-Lysholm activity score, Lysholm-Giliquist score, ICRS score) as well as the results of six arthroscopies and biopsies obtained from four patients formed the basis of this study. For 15 patients, 5 or more years had elapsed since the operation at the time this study was completed. It was possible to obtain results 5 years postoperatively from 11 (73.3%) of these 15 patients. Overall, we included 25 patients into the evaluation with a 2-year or longer postoperative period.Five years after transplantation 8 out of 11 patients rated the function of their knee as much better or better than before. Three of the four scores showed significant improvement compared to the preoperative value. One score, the Tegner-Lysholm score showed improvement, which, however, did not prove to be significant.The significantly improved results on three scores after 5 years suggest that MACT represents a suitable but cost-intensive alternative in the treatment of local cartilage defects in the knee. (C) 2006 Elsevier B.V. All rights reserved.