IL-18, TNF, and IFN- alleles and genotypes are associated with susceptibility to chronic hepatitis B infection and severity of liver injury
IL-18, TNF, and IFN- alleles and genotypes are associated with susceptibility to chronic hepatitis B infection and severity of liver injury
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DOI：
10.1002/jmv.24225
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发表时间：
2015-10-01
影响因子：
12.7
通讯作者：
Candolo Martinelli, Ana de Lourdes
中科院分区：
文献类型：
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作者：
Ferreira, Sandro da Costa;Florencio Chacha, Silvana Gama;Candolo Martinelli, Ana de Lourdes
本研究评估了IL-18（-607 C/A和-137 C/G）、IFN（+874 A/T）和TNF（-238 A/G和-308 A/G）基因多态性与HBV感染易感性和肝损伤严重程度的相关性。共有259名慢性HBV感染者在巴西圣保罗RibeirAo Preto大学医院医学院进行了研究，并对202名健康个体进行了研究。采用聚合酶链反应（PCR）扩增4个单核苷酸多态性（SNPs）。对212例HBV感染患者进行肝活检，并根据肝纤维化的严重程度（评分0 - 4）和坏死性炎症活动（HAI评分0 - 18）进行分类。TNF-308 * A等位基因（P
This study evaluated the association of polymorphisms in the IL-18 (-607C/A and -137C/G), IFN (+874 A/T), and TNF (-238 A/G and -308 A/G) genes with susceptibility to HBV infection and severity of liver injury. A total of 259 chronic HBV-infected patients followed at the University Hospital, Faculty of Medicine of RibeirAo Preto, SAo Paulo, Brazil, and 202 healthy individuals were studied. Four Single Nucleotide Polymorphisms (SNPs) were amplified by Polymerase Chain Reaction (PCR). Liver biopsy was performed in 212 HBV-infected patients and classified according to severity of liver fibrosis (scores 0-4) and necroinflammatory activity (HAI scores 0-18). TNF-308*A allele (P