The thymus exports long-lived fully committed T cell precursors that can colonize primary lymphoid organs
The thymus exports long-lived fully committed T cell precursors that can colonize primary lymphoid organs
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DOI：
10.1038/ni1293
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发表时间：
2006-01-01
影响因子：
30.5
通讯作者：
Ezine, S
中科院分区：
文献类型：
--
作者：
Lambolez, F;Arcangeli, ML;Ezine, S
胸腺细胞的输出被认为仅限于成熟的T细胞。在这里，我们表明胸腺也输出完全承诺的T细胞前体，定植原发性淋巴器官。这些前体细胞在T细胞受体重排之前离开胸腺，并定植胸腺和肠道等淋巴器官。胸腺T细胞前体的迁移导致肠道前体室的永久定植，提高了肠道前体进一步分化为T细胞的能力，并足以产生“胸腺样”CD8 α α(+)上皮内淋巴细胞。这些数据证明了胸腺在外周植入T细胞前体时的新功能，这些T细胞前体在胸腺输出后变得长寿。
Thymic export of cells is believed to be restricted to mature T cells. Here we show that the thymus also exports fully committed T cell precursors that colonize primary lymphoid organs. These precursor cells exited the thymus before T cell receptor rearrangements and colonized lymphoid organs such as the thymus and the gut. Migration of the thymic T cell-committed precursors led to permanent colonization of the gut precursor compartment, improved the capacity of gut precursors to further differentiate into T cells and was sufficient for the generation of 'euthymic like' CD8 alpha alpha(+) intraepithelial lymphocytes. These data demonstrate a new function for the thymus in peripheral seeding with T cell precursors that become long lived after thymus export.