PROPRANOLOL TREATMENT OF ASSAULTIVE PATIENTS WITH ORGANIC BRAIN DISEASE - A DOUBLE-BLIND CROSSOVER, PLACEBO-CONTROLLED STUDY
PROPRANOLOL TREATMENT OF ASSAULTIVE PATIENTS WITH ORGANIC BRAIN DISEASE - A DOUBLE-BLIND CROSSOVER, PLACEBO-CONTROLLED STUDY
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DOI：
10.1097/00005053-198605000-00005
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发表时间：
1986-05-01
影响因子：
1.9
通讯作者：
WOOTTON, J
中科院分区：
文献类型：
--
作者：
GREENDYKE, RM;KANTER, DR;WOOTTON, J
进行了一项双盲、安慰剂对照的交叉研究，以检查长效普萘洛尔在治疗10名患者中与器质性脑病相关的暴力行为的效果，这些患者的症状已被证明对各种常规药物无效。长效普萘洛尔治疗与攻击行为的减少有关，但没有明显的镇静作用。注意潜在的不良副作用，这可能需要在治疗期间仔细监测患者。
A double-blind, placebo-controlled crossover study was conducted to examine the effects of long-acting propranolol in the treatment of violent behavior associated with organic brain disease in 10 patients whose symptoms had proved refractory to various conventional medications. Long-acting propranolol treatment was associated with reductions of assaultive behavior without apparent sedative effects. Cautions are noted regarding potential undesirable side effects which may necessitate careful patient monitoring during treatment.