Ischemic tolerance in the cochlea
Ischemic tolerance in the cochlea
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DOI：
10.1016/j.neulet.2009.07.019
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发表时间：
2009-09-25
影响因子：
2.5
通讯作者：
Gyo, Kiyofumi
中科院分区：
文献类型：
--
作者：
Takeda, Shoichiro;Hata, Ryuji;Gyo, Kiyofumi
在沙土鼠耳蜗性缺血模型上，研究了耳蜗区的缺血耐受性。颅外阻断双侧椎动脉造成一过性耳蜗性缺血。将沙土鼠分为两组：单纯缺血组和双重缺血组。单纯缺血组动物致死性耳蜗性缺血15min。双重缺血组动物在致死性缺血前2d进行耳蜗亚致死性缺血2min，15min。因此，亚致死性缺血阻止了致命性缺血诱导的毛细胞退化，并改善了听力障碍，表明耳蜗组织对缺血耐受。(C)2009爱思唯尔爱尔兰有限公司。保留所有权利。
Ischemic tolerance in the cochlea was investigated in a gerbil model of cochlear ischemia. Transient cochlear ischemia was produced by extracranial occlusion of the bilateral vertebral arteries. The gerbils were divided into two groups; single ischemia group and double ischemia group. In the single ischemia group, animals were subjected to lethal cochlear ischemia for 15 min. In the double ischemia group, animals were subjected to sublethal cochlear ischemia for 2 min at 2 days before lethal ischemia for 15 min. Consequently, sublethal ischemia prevented lethal ischemia-induced hair cell degeneration and ameliorated hearing impairment, suggesting ischemic tolerance in the cochlea. (c) 2009 Elsevier Ireland Ltd. All rights reserved.