The field of tissue injury in the lung and airway.
The field of tissue injury in the lung and airway.
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DOI：
10.1158/1940-6207.capr-08-0174
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发表时间：
2008-11
期刊：
影响因子：
--
通讯作者：
Spira A
中科院分区：
文献类型：
--
作者：
Steiling K;Ryan J;Brody JS;Spira A
现场癌变的概念是在六十多年前首次引入口腔癌的设置。后来，涉及肿瘤和邻近组织的组织学和分子变化的现场癌变开始在吸烟者中表现为肺癌或非肺癌。研究人员还描述了一个弥漫性的，非肿瘤领域的分子损伤整个呼吸道，这是由于吸烟和吸烟诱发的肺部疾病的易感性。肺和气道上皮细胞暴露于香烟烟雾后的场癌变和损伤场的潜在分子起源对于理解损伤场对吸烟诱导的肺病的临床诊断和治疗的影响至关重要。
The concept of field cancerization was first introduced over six decades ago in the setting of oral cancer. Later, field cancerization involving histologic and molecular changes of neoplasms and adjacent tissue began to be characterized in smokers with or without lung cancer. Investigators also described a diffuse, non-neoplastic field of molecular injury throughout the respiratory tract that is attributable to cigarette smoking and susceptibility to smoking-induced lung disease. The potential molecular origins of field cancerization and the field of injury following cigarette smoke exposure in lung and airway epithelia are critical to understanding the impact of the field of injury on clinical diagnostics and therapeutics for smoking-induced lung disease.