Prognostic significance of the T2 substage in patients with esophageal squamous cell carcinoma
Prognostic significance of the T2 substage in patients with esophageal squamous cell carcinoma
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T2亚期对食管鳞癌患者预后的意义
DOI：
10.1093/dote/dow027
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发表时间：
2017
影响因子：
2.6
通讯作者：
Ba Y.
中科院分区：
文献类型：
--
作者：
Duan J.;Deng T.;Ying G.;Zhang H.;Zhou L.;Bai M.;Li H.;Ba Y.
食管鳞癌侵犯固有肌层为T2期。关于基于解剖学的T2亚期是否可以作为预后指标，缺乏证据。本研究旨在证实T2亚期的预后价值。方法回顾性分析2006 - 2011年天津医科大学附属肿瘤医院收治的120例经病理证实的T2肿瘤患者的临床病理特征。根据浸润深度，已穿透环形肌层的肿瘤定义为T2 a，而T2 b疾病是指已侵入纵向肌层的肿瘤。采用单变量和多变量分析方法对可能与生存率相关的因素进行分析。采用Logistic回归模型分析淋巴结转移的相关因素。为了进一步验证T2分期的预后价值，选择同期T1 b和T3分期的患者进行比较。单因素和多因素分析表明，T2分期和N分期是独立的预后因素。Logistic回归分析显示T2分期与淋巴结转移密切相关（P= 0.044）。当考虑T1 b和T3时，T2 a患者的生存率更接近T1 b患者，而T2 b患者的生存率更接近T3疾病（P= 0.000）。T2分期是独立的预后因素。T2 a肿瘤患者的生存率较好，而T2 b患者的预后更接近T3患者。
The invasion of the muscularis propria is defined as T2 stage in esophageal squamous cell carcinoma. Evidence is lacking regarding whether the T2 substage based on anatomy may serve as a prognostic indicator. This study aims to confirm the prognostic value of the T2 substage. The clinicopathological characteristics of 120 patients who had pathologically verified T2 tumors between 2006 and 2011 at the Tianjin Medical University Cancer Institute and Hospital were retrospectively studied. Based on the invasion depth, tumors that had penetrated the circular muscle layer were defined as T2a, while T2b disease referred to those that had invaded the longitudinal muscle layer. Factors potentially related to survival were analyzed with univariate and multivariate analyses. The logistic regression model was used to examine the factors associated with lymph node metastasis. To verify the prognostic value of the T2 substage further, patients with T1b and T3 stage disease during the same period were selected for comparisons. The univariate and multivariate analyses demonstrated that the T2 substage and N stage were independent prognostic factors. The T2 substage was highly relevant to lymph node metastasis in the logistic regression model (P= 0.044). When T1b and T3 was considered, the survival of T2a patients was closer to that of T1b patients, while the survival of T2b patients was closer to that of T3 disease (P= 0.000). The T2 substage was an independent prognostic factor. Patients with T2a tumors displayed a favorable survival, while the prognosis of T2b patients was closer to that of T3 patients.