Polymorphisms in the ICAM1 gene predict circulating soluble intercellular adhesion molecule-1(sICAM-1)
Polymorphisms in the ICAM1 gene predict circulating soluble intercellular adhesion molecule-1(sICAM-1)
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DOI：
10.1016/j.atherosclerosis.2011.02.018
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发表时间：
2011-06-01
期刊：
影响因子：
5.3
通讯作者：
Gross, Myron D.
中科院分区：
文献类型：
--
作者：
Bielinski, Suzette J.;Reiner, Alex P.;Gross, Myron D.
目的：ICAM1 结构基因内的多态性已被证明会影响可溶性细胞间粘附分子-1 (sICAM-1) 的循环水平，但其与动脉粥样硬化的关系尚未明确。我们试图确定 ICAM1 SNP 是否与循环 sICAM-1 浓度、冠状动脉钙 (CAC) 以及颈总动脉和颈内动脉内膜内侧厚度 (IMT) 相关。方法和结果：3550 名黑白青年冠状动脉风险发展 (CARDIA) 研究对象参加了 15 和/或 20 年检查，并且是青年抗氧化剂纵向研究 (YALTA) 的一部分该分析中包括了辅助研究。在白人中，rs5498 与 sICAM-1 显着相关（p < 0.001），rs5498 的每个 G 等位基因与高出 5% 的 sICAM-1 浓度相关。在黑人中，rs5490 的每个 C 等位基因与 6% 的 sICAM-1 水平升高相关；该SNP与功能变异体rs5491存在强连锁不平衡。第 15 年或第 20 年动脉粥样硬化的亚临床测量与 ICAM1 SNP 没有显着相关。结论：在 CARDIA 中，ICAM1 DNA 片段变异与 sICAM-1 蛋白水平相关，包括新发现功能变异 rs5491 导致水平不同。然而，ICAM1 SNP 与 IMT 或 CAC 没有很强的相关性。我们在 CARDIA 中的研究结果表明，ICAM1 变异并不是亚临床动脉粥样硬化的主要早期促成因素。 (C) 2011 Elsevier Ireland Ltd. 保留所有权利。
Objective: Polymorphisms within the ICAM1 structural gene have been shown to influence circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) but their relation to atherosclerosis has not been clearly established. We sought to determine whether ICAM1 SNPs are associated with circulating sICAM-1 concentration, coronary artery calcium (CAC), and common and internal carotid intima medial thickness (IMT).Methods and Results: 3550 black and white Coronary Artery Risk Development in Young Adults (CARDIA) Study subjects who participated in the year 15 and/or 20 examinations and were part of the Young Adult Longitudinal Study of Antioxidants (YALTA) ancillary study were included in this analysis. In whites, rs5498 was significantly associated with sICAM-1 (p < 0.001) and each G-allele of rs5498 was associated with 5% higher sICAM-1 concentration. In blacks, each C-allele of rs5490 was associated with 6% higher sICAM-1 level; this SNP was in strong linkage disequilibrium with rs5491, a functional variant. Subclinical measurements of atherosclerosis in either year 15 or year 20 were not significantly related to ICAM1 SNPs.Conclusions: In CARDIA, ICAM1 DNA segment variants were associated with sICAM-1 protein level including the novel finding that levels differ by the functional variant rs5491. However, ICAM1 SNPs were not strongly related to either IMT or CAC. Our findings in CARDIA suggest that ICAM1 variants are not major early contributors to subclinical atherosclerosis. (C) 2011 Elsevier Ireland Ltd. All rights reserved.