Outcomes of patients with bone metastases from differentiated thyroid cancer.
Outcomes of patients with bone metastases from differentiated thyroid cancer.
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DOI：
10.20945/2359-3997000000004
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发表时间：
2018-02
影响因子：
1.7
通讯作者：
Pitoia, Fabian
中科院分区：
文献类型：
--
作者：
Califano, Ines;Deutsch, Susana;Lowenstein, Alicia;Cabezon, Carmen;Pitoia, Fabian
Bone metastases (BM) from differentiated thyroid cancer (DTC) are associated with poor survival rates. Due to the low frequency of this entity, we performed a multicentric retrospective study that aimed to evaluate the presentation, outcome and causes of death in this population. We reviewed file records from 10 databases. BM were diagnosed by: i) biopsy and/or ii) radioiodine (RAI) bone uptake + elevated thyroglobulin (Tg) levels and/or c) bone uptake of 18-FDG in the PET-CT scan + elevated Tg levels. Fifty-two patients with DTC were included (44% male, mean age 54 years); 58% had papillary histology. BM were synchronous with DTC diagnosis in 46% of the participating cases. BM were symptomatic in 65% of the cases. Multiple BM were present in 65% of patients, while simultaneous metastatic disease in additional sites was found in 69%. Ninety-eight percent of patients received treatment for the BM, which included RAI therapy in 42 patients; 30 of them received cumulative RAI doses that were larger than 600 mCi 131I. The mean follow-up after a BM diagnosis was 34 months. The 2- and 5-year survival rates after diagnosis of the first BM were 64% and 38%, respectively. The status on the last evaluation was DTC-related death in 52% of the patients; 26% of them died from direct complications of BM or their treatments. BM are usually radioiodine-refractory and are associated with a short overall survival, although most of the patients died of causes not directly related to the BM.
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影响因子：
5.8
作者：
Durante, C.;Haddy, N.;Schlumberger, M.
通讯作者：
Schlumberger, M.
影响因子：
5.8
作者：
Eustatia-Rutten, CFA;Corssmit, EPM;Smit, JW
通讯作者：
Smit, JW
DOI：
10.4103/1947-2714.170600
发表时间：
2015-11
期刊：
North American journal of medical sciences
影响因子：
--
作者：
Mirrakhimov AE
通讯作者：
Mirrakhimov AE
影响因子：
5.8
作者：
Qiu, Zhong-Ling;Song, Hong-Jun;Luo, Quan-Yong
通讯作者：
Luo, Quan-Yong
影响因子：
6.6
作者：
Pittas, AG;Adler, M;Robbins, RJ
通讯作者：
Robbins, RJ