Pathogenesis of NASH: animal models.
Pathogenesis of NASH: animal models.
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DOI：
10.1016/j.cld.2007.02.010
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发表时间：
2007-02-01
影响因子：
5.1
通讯作者：
George, Jacob
中科院分区：
文献类型：
--
作者：
London, Roslyn M;George, Jacob
非酒精性脂肪性肝炎是一种与内脏肥胖、胰岛素抵抗、血脂异常和2型糖尿病有关的疾病，其发病率随着代谢综合征患病率的上升而增加。本文主要介绍脂肪性肝炎动物模型的研究进展，包括：(1)调节肝脏脂肪、葡萄糖和胆固醇动态平衡的机制；(2)脂肪变性肝脏的炎症募集和纤维化形成。这项研究的最终目的是深入了解肝脏脂质、炎症和纤维化在人类非酒精性脂肪性肝病中的作用。
The incidence of non-alcoholic steatohepatitis, a disorder linked to visceral adiposity, insulin resistance, dyslipidemia, and type 2 diabetes mellitus, is increasing with the rise in the prevalence of the metabolic syndrome. This review focuses on animal models of steatohepatitis currently used to study (1) the mechanisms regulating hepatic lipid, glucose, and cholesterol homeostasis and (2) inflammatory recruitment and fibrogenesis in the steatotic liver. The ultimate aim of this research is to gain insights into the role of hepatic lipid, inflammation, and fibrosis in human non-alcoholic fatty liver disease.