Microbiota transplantation: Targeting cancer treatment
Microbiota transplantation: Targeting cancer treatment
复制标题
微生物群移植：靶向癌症治疗
DOI：
10.1016/j.canlet.2019.03.010
复制
发表时间：
2019
期刊：
影响因子：
9.7
通讯作者：
Zhang Faming
中科院分区：
文献类型：
--
作者：
Wu Xia;Zhang Ting;Chen Xiong;Ji Guozhong;Zhang Faming
越来越多的证据表明，肠道微生物群在癌症患者对化疗、放疗和免疫治疗的治疗反应中起着关键作用，包括临床疗效和对毒性的敏感性。这些迷人的发现唤起了操纵肠道微生物群以优化从实验室到旁边的抗癌治疗的可能性。微生物群移植（MT），包括粪便微生物群移植（FMT）和选择性微生物群移植（SMT），可以提高抗癌治疗的效果和/或减少相关的副作用。MT在肿瘤治疗中的安全性和有效性是该领域转化研究的核心，这启发我们关注MT靶向抗癌治疗的MT技术和机制。在专用实验室中通过机器进行基于自动方法的清洁FMT已成为现实。结肠镜下肠管作为一种新型的MT给药方式，为临床上的频繁给药提供了方便，也为研究中的疗效确认提供了可行的工具。本文就近年来微生物群在化疗、放疗和免疫治疗中的作用以及MT在抗癌治疗中的方法学、可行性和挑战作一综述。
Mounting evidence have demonstrated that gut microbiota plays a critical role in cancer patients’ therapeutic responses to chemotherapy, radiotherapy and immunotherapy, including clinical efficacy and sensitivity to toxicity. These fascinating findings evoke a possibility of manipulating gut microbiota to optimize anti-cancer treatment from bench to beside. Microbiota transplantation (MT), including fecal microbiota transplantation (FMT) and selective microbiota transplantation (SMT), may improve the effect of anti-cancer treatment and/or reduce the related side effects. The safety and efficacy of MT in cancer treatment are the core of translational research in this promising field, which inspire us to focus on the MT technology and mechanism of MT targeting anti-cancer treatment. To perform clean FMT based on automatic methods by machine in exclusive laboratory has become true. Colonic transendoscopic enteral tubing as a novel delivering way for MT should bring convenience for frequent delivering in practice and feasible tool for confirming the therapeutic effect in research. The present review focuses on the recent findings on role of microbiota on chemotherapy, radiotherapy and immunotherapy, and the methodology, feasibility and challenges of MT in anti-cancer treatment.