Physicochemical Properties of Ion Pairs of Biological Macromolecules.
Physicochemical Properties of Ion Pairs of Biological Macromolecules.
复制标题
生物大分子离子对的物理化学特性。
DOI：
10.3390/biom5042435
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发表时间：
2015-09-30
期刊：
影响因子：
5.5
通讯作者：
Zandarashvili L
中科院分区：
文献类型：
--
作者：
Iwahara J;Esadze A;Zandarashvili L
静电相互作用的阳离子和阴离子部分的离子对（也称为作为盐桥）对于蛋白质和核酸执行其功能是重要的。虽然许多三维结构显示在生物大分子及其复合物的功能上重要的位点上的离子对，但是离子对的物理化学性质还没有被很好地理解。晶体结构通常显示每个离子对的单一状态。然而，最近的研究揭示了生物大分子离子对的动力学性质。生物分子离子对在不同状态之间经历动态转变，其中带电部分直接接触或被水分离。根据上个世纪为小离子建立的基本概念，这种动态行为是合理的。本文介绍了与离子对相关的物理化学概念，并对生物大分子离子对的生物物理研究进展进行了综述。
Ion pairs (also known as salt bridges) of electrostatically interacting cationic and anionic moieties are important for proteins and nucleic acids to perform their function. Although numerous three-dimensional structures show ion pairs at functionally important sites of biological macromolecules and their complexes, the physicochemical properties of the ion pairs are not well understood. Crystal structures typically show a single state for each ion pair. However, recent studies have revealed the dynamic nature of the ion pairs of the biological macromolecules. Biomolecular ion pairs undergo dynamic transitions between distinct states in which the charged moieties are either in direct contact or separated by water. This dynamic behavior is reasonable in light of the fundamental concepts that were established for small ions over the last century. In this review, we introduce the physicochemical concepts relevant to the ion pairs and provide an overview of the recent advancement in biophysical research on the ion pairs of biological macromolecules.