Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
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DOI：
10.1126/science.280.5370.1750
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发表时间：
1998-06-12
期刊：
影响因子：
56.9
通讯作者：
Storb, U
中科院分区：
文献类型：
--
作者：
Shen, HM;Peters, A;Storb, U
免疫球蛋白（Ig）基因在B淋巴细胞中发生超突变，B淋巴细胞是记忆B细胞的前体。突变与转录起始有关，但突变过程允许非ig启动子；因此，在突变的B细胞中表达的其他基因也可能受到体细胞超突变的影响。在c-MYC、S14或甲胎蛋白（AFP）基因中未观察到显著突变，但BCL-6在正常人的大部分记忆B细胞中高度突变。突变模式与Ig基因相似。
Immunoglobulin (Ig) genes are hypermutated in B lymphocytes that are the precursors to memory B cells. The mutations are linked to transcription initiation, but non-Ig promoters are permissible for the mutation process; thus, other genes expressed in mutating B cells may also be subject to somatic hypermutation. Significant mutations were not observed in c-MYC, S14, or alpha-fetoprotein (AFP) genes, but BCL-6 was highly mutated in a large proportion of memory B cells of normal individuals. The mutation pattern was similar to that of Ig genes.