DOLICHOL - FUNCTION, METABOLISM, AND ACCUMULATION IN HUMAN TISSUES
DOLICHOL - FUNCTION, METABOLISM, AND ACCUMULATION IN HUMAN TISSUES
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DOI：
10.1139/o92-059
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发表时间：
1992-06-01
影响因子：
2.9
通讯作者：
RAVI, K
中科院分区：
文献类型：
--
作者：
CARROLL, KK;GUTHRIE, N;RAVI, K
DOLICHOL是一类含有14-24个异戊二烯单元的α-饱和聚异戊二烯醇类化合物，大约30年前首次被分离和表征。磷酸化形式是生物合成重要的N-连接糖蛋白所必需的。多元醇本身是由醋酸酯通过常见的类异戊二烯途径合成的，合成可以被一些抑制胆固醇生物合成的因素所抑制。它的新陈代谢非常慢，在衰老过程中和某些脂肪储存疾病中在组织中积累。Dolichyl磷酸和胆固醇在衰老过程中也会在组织中积累，但程度比Dolichyl要小。虽然多元醇和胆固醇具有重要的新陈代谢功能，但它们在组织中的积累可能会产生有害影响。
Dolichol, a homologous series of alpha-saturated polyisoprenoid alcohols containing 14-24 isoprene units, was first isolated and characterized about 30 years ago. The phosphorylated form, dolichyl phosphate, is required for the biosynthesis of biologically important N-linked glycoproteins. Dolichol itself is synthesized by a common isoprenoid pathway from acetate and synthesis can be inhibited by some of the factors that inhibit cholesterol biosynthesis. It is metabolized very slowly and accumulates in tissues during aging and in certain lipid storage diseases. Dolichyl phosphate and cholesterol also accumulate in tissues during aging, but to a lesser extent than dolichol. Although dolichol and cholesterol have important metabolic functions, their accumulation in tissues can have deleterious effects.