Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology.
Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology.
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DOI：
10.1155/2018/6290931
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发表时间：
2018
影响因子：
--
通讯作者：
Vicente JB
中科院分区：
文献类型：
--
作者：
Giuffrè A;Vicente JB
硫化氢（H2S）是一种与一氧化氮（NO）和一氧化碳（CO）类似的气体递质，在生理学上是一种相关的信号分子。在仅仅被认为是一种有毒的有毒分子之后，现在人们认识到哺乳动物细胞具有复杂的酶系统来产生和分解H2S。H2S的信号传导作用主要与其修饰不同蛋白质靶标的能力有关，特别是通过促进蛋白质半胱氨酸残基的过硫化以及通过与金属中心（主要是血红素）相互作用。H2S已被证明调节具有多种生理后果的无数细胞过程。因此，H2S代谢功能失调越来越多地涉及从心血管和神经退行性疾病到癌症等不同病理学。作为一种高度扩散的活性物质，H2S的细胞内和细胞外水平必须保持在严格的控制下，因此，H2S代谢的调节发生在不同的水平。有趣的是，尽管H2S、NO和CO具有相似的作用模式和平行的调节目标，或者正因为如此，越来越多的证据表明这三种气体递质之间存在串扰。本文综述了硫化氢的生物化学、代谢、信号传导功能及其与其他气体递质NO和CO的相互作用。
Hydrogen sulfide (H2S) has emerged as a relevant signaling molecule in physiology, taking its seat as a bona fide gasotransmitter akin to nitric oxide (NO) and carbon monoxide (CO). After being merely regarded as a toxic poisonous molecule, it is now recognized that mammalian cells are equipped with sophisticated enzymatic systems for H2S production and breakdown. The signaling role of H2S is mainly related to its ability to modify different protein targets, particularly by promoting persulfidation of protein cysteine residues and by interacting with metal centers, mostly hemes. H2S has been shown to regulate a myriad of cellular processes with multiple physiological consequences. As such, dysfunctional H2S metabolism is increasingly implicated in different pathologies, from cardiovascular and neurodegenerative diseases to cancer. As a highly diffusible reactive species, the intra- and extracellular levels of H2S have to be kept under tight control and, accordingly, regulation of H2S metabolism occurs at different levels. Interestingly, even though H2S, NO, and CO have similar modes of action and parallel regulatory targets or precisely because of that, there is increasing evidence of a crosstalk between the three gasotransmitters. Herein are reviewed the biochemistry, metabolism, and signaling function of hydrogen sulfide, as well as its interplay with the other gasotransmitters, NO and CO.
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