Impact of level and patterns of alcohol drinking on coronary heart disease and stroke burden in Argentina.
Impact of level and patterns of alcohol drinking on coronary heart disease and stroke burden in Argentina.
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DOI：
10.1371/journal.pone.0173704
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Danaei G
中科院分区：
文献类型：
--
作者：
Bardach AE;Caporale JE;Rubinstein AL;Danaei G
拉丁美洲因心血管疾病 (CVD)，包括冠心病 (CHD) 和中风导致的死亡预计将会增加。适量、经常饮酒可以保护心血管，而酗酒则会增加风险。我们估计了阿根廷饮酒对每年冠心病和中风死亡人数以及伤残调整生命年 (DALY) 的影响。酒精使用数据来自全国代表性调查（EnPreCosp 2011），病因学效应大小来自流行病学研究的荟萃分析。特定原因死亡率来自生命登记系统。 2010年共有291,475人死亡，其中24,893人死于冠心病，15,717人死于中风。 62.7% 的男性和 38.7% 的女性表示去年曾饮酒。所有重度饮酒者（即每天饮酒量 > 20 克的女性和每天饮酒量 > 40 克的男性）均符合酗酒的定义，因此无法从心脏保护作用中受益。饮酒每年可预防 1,424 例 CHD 死亡，但导致 935 例中风死亡（121 例缺血性死亡，814 例出血性死亡），从而预防 448 例 CVD 死亡（男性占 58.3%）。据估计，饮酒可以使 85,772 名因冠心病而丧失劳动能力的生命年 (DALY) 减少，但会导致 52,171 人因中风而死亡。在阿根廷，经常适量饮酒对心脏的保护作用略大于酗酒对心血管疾病的有害影响。然而，考虑到酒精对全球公共健康的有害影响，应该执行减少酗酒的政策，特别是针对年轻人。仍需要研究来阐明对心血管健康的影响。
Deaths from cardiovascular disease (CVD), including coronary heart disease (CHD) and stroke are expected to increase in Latin America. Moderate and regular alcohol consumption confers cardiovascular protection, while binge drinking increases risk. We estimated the effects of alcohol use on the number of annual CHD and stroke deaths and disability-adjusted life years (DALYs) in Argentina. Alcohol use data were obtained from a nationally representative survey (EnPreCosp 2011), and etiological effect sizes from meta-analyses of epidemiological studies. Cause-specific mortality rates were from the vital registration system. There were 291,475 deaths in 2010 including 24,893 deaths from CHD and 15,717 from stroke. 62.7% of men and 38.7% of women reported drinking alcohol in the past year. All heavy drinkers (i.e. women who drank >20g/day and men who drank >40g/day of alcohol) met the definition of binge drinking and therefore did not benefit from cardioprotective effects. Alcohol drinking prevented 1,424 CHD deaths per year but caused 935 deaths from stroke (121 ischemic and 814 hemorrhagic), leading to 448 CVD deaths prevented (58.3% in men). Alcohol use was estimated to save 85,772 DALYs from CHD, but was responsible for 52,171 lost from stroke. In Argentina, the cardioprotective effect of regular and moderate alcohol drinking is slightly larger than the harmful impact of binge drinking on CVD. However, considering global deleterious effects of alcohol in public health, policies to reduce binge drinking should be enforced, especially for young people. Studies are still needed to elucidate effects on cardiovascular health.