Biophysical signals controlling cell fate decisions: How do stem cells really feel?
Biophysical signals controlling cell fate decisions: How do stem cells really feel?
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DOI：
10.1016/j.biocel.2012.09.003
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发表时间：
2012-12-01
影响因子：
4
通讯作者：
Connelly, John T.
中科院分区：
文献类型：
--
作者：
Costa, Patricia;Almeida, Filipe V. M.;Connelly, John T.
自我更新和分化是基本的干细胞命运决定，这对于正常组织发育、稳态和修复是必不可少的。细胞外信号，包括机械力和生物物理力，在指导各种干细胞和祖细胞的行为中起着重要作用，最近的研究为这些反应的分子机制提供了新的见解。当整联蛋白受体将力从细胞外基质传递到细胞时，肌动蛋白细胞骨架和Rho-GTP酶介导下游信号转导。然而，为了影响干细胞的命运，这些信号级联必须最终被转导成特定的转录反应。血清反应因子（SRF）和yes相关蛋白（雅普）是机械敏感性转录因子的两个例子，最近被认为与表皮和间充质干细胞分化有关。未来研究的重大挑战可能包括测量细胞在体内经历的相关生物物理力，并将现有知识转化为再生疗法。(C)2012爱思唯尔有限公司保留所有权利。
Self-renewal and differentiation are fundamental stem cell fate decisions, which are essential for normal tissue development, homeostasis, and repair. Extracellular signals, including mechanical and biophysical forces, play an important role in directing the behaviour of a variety of stem and progenitor cells, and recent studies have provided new insights into the molecular mechanisms of these responses. While integrin receptors transmit forces from the extracellular matrix to the cell, the actin cytoskeleton and Rho-GTPases, mediate downstream signal transduction. To affect stem cell fate, however, these signalling cascades must ultimately be transduced into specific transcription responses. Serum response factor (SRF) and yes-associated protein (YAP) are two examples of mechano-sensitive transcription factors, which have recently been implicated in epidermal and mesenchymal stem cell differentiation. Significant challenges for future studies will likely include measuring the relevant biophysical forces experienced by cells in vivo and translating the current knowledge into regenerative therapies. (C) 2012 Elsevier Ltd. All rights reserved.