BRONCHOALVEOLAR LAVAGE FOR DIAGNOSING ACUTE BACTERIAL PNEUMONIA
BRONCHOALVEOLAR LAVAGE FOR DIAGNOSING ACUTE BACTERIAL PNEUMONIA
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DOI：
10.1093/infdis/155.5.855
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发表时间：
1987-05-01
影响因子：
6.4
通讯作者：
STANECK, JL
中科院分区：
文献类型：
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作者：
THORPE, JE;BAUGHMAN, RP;STANECK, JL
对92例急性细菌性肺炎患者行支气管肺泡灌洗(BAL)取液革兰氏染色和半定量培养鉴定病原体的价值进行了初步评价。其中15名患者表现为临床活动性细菌性肺炎；其余患者接受了支气管镜检查，以评估肺部的其他过程。在15名临床活动性细菌性肺炎患者中，有13人进行了BAL培养。10 5个菌落形成单位/毫升BAL液，而其他组均无阳性培养(X2=70.7，P<；0.001)。细胞离心液的革兰氏染色呈阳性(每1000次可见一种或多种微生物。仅限于那些患有活动性细菌性肺炎的患者。应用这项技术，我们研究了59名表现为肺浸润物的免疫功能低下的患者。39例患者中有8例(21%)经BAL培养证实患有急性细菌性肺炎；肺炎经适当的抗菌治疗后痊愈。
The utility of gram stain and semiquantitative culture of the fluid retrieved by bronchoalveolar lavage (BAL) in identifying the causative agent in acute bacterial pneumonia was initially assessed in 92 patients. Fifteen of these patients presented with clinically active bacterial pneumonia; the remaining patients underwent bronchoscopy to evaluate other processes in the lung. Thirteen of the 15 patients with clinically active bacterial pneumonia had a BAL culture .gtoreq. 105 colony-forming units per milliliter of BAL fluid, whereas none of the other groups had a positive culture (X2 = 70.7, P < 0.001). Gram stain of cytocentrifuged BAL fluid was positive (one or more organisms seen per 1,000 .times. field) only in those patients with an active bacterial pneumonia. Applying this technique, we studied 59 immunocompromised patients presenting with pulmonary infiltrates. Eight (21%) of the 39 patients presenting with microbial-related infiltrates proved to have acute bacterial pneumonia by BAL culture; the pneumonia resolved with appropriate antimicrobial therapy.