THE HUMAN IMMUNODEFICIENCY VIRUS - INFECTIVITY AND MECHANISMS OF PATHOGENESIS
THE HUMAN IMMUNODEFICIENCY VIRUS - INFECTIVITY AND MECHANISMS OF PATHOGENESIS
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DOI：
10.1126/science.3277274
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发表时间：
1988-02-05
期刊：
影响因子：
56.9
通讯作者：
FAUCI, AS
中科院分区：
文献类型：
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作者：
FAUCI, AS
人类免疫缺陷病毒（HIV）感染导致严重的免疫抑制，主要是由于表达病毒受体（CD 4分子）的辅助/诱导T淋巴细胞的选择性耗竭。艾滋病毒还对大脑有嗜性，导致神经精神异常。除了诱导细胞死亡外，艾滋病毒还可以通过多种机制干扰T4细胞功能。单核细胞作为HIV的储存库，并且对其细胞病变效应相对难治。HIV可以潜伏或慢性形式存在，可以通过各种诱导信号转化为生产性感染。
Infection with the human immunodeficiency virus (HIV) results in a profound immunosuppression due predominantly to a selective depletion of helper/inducer T lymphocytes that express the receptor for the virus (the CD4 molecule). HIV also has tropism for the brain leading to neuropsychiatric abnormalities. Besides inducing cell death, HIV can interfere with T4 cell function by various mechanisms. The monocyte serves as a reservoir for HIV and is relatively refractory to its cytopathic effects. HIV can exist in a latent or chronic form which can be converted to a productive infection by a variety of inductive signals.