Circular RNA hsa_circ_0008344 regulates glioblastoma cell proliferation, migration, invasion, and apoptosis
Circular RNA hsa_circ_0008344 regulates glioblastoma cell proliferation, migration, invasion, and apoptosis
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环状RNA hsa_circ_0008344 调节胶质母细胞瘤细胞增殖、迁移、侵袭和凋亡
DOI：
10.1002/jcla.22454
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发表时间：
2018-09-01
影响因子：
2.7
通讯作者：
Wang, Yuhai
中科院分区：
文献类型：
--
作者：
Zhou, Jinxu;Wang, Hongxiang;Wang, Yuhai
BackgroundRecent studies have found circular RNAs (circRNAs) involved in the biological process of cancers. However, little is known about their functional roles in glioblastoma.MethodsHuman circRNA microarray analysis was performed to screen the expression profile of circRNAs in IDH1 wild-type glioblastoma tissue. The expression of hsa_circ_0008344 in glioblastoma and normal brain samples was quantified by qRT-PCR. Functional experiments were performed to investigate the biological functions of hsa_circ_0008344, including MTT assay, colony formation assay, transwell assay, and cell apoptosis assay.ResultsCircRNA microarray revealed a total of 417 abnormally expressed circRNAs (>1.5-fold, P
