Effects of Nitroglycerin on Echocardiographic Measurements of Left Ventricular Wall Thickness Regional Myocardial Performance During Acute Coronary Ischemia
Effects of Nitroglycerin on Echocardiographic Measurements of Left Ventricular Wall Thickness Regional Myocardial Performance During Acute Coronary Ischemia
复制标题
硝酸甘油对急性冠状动脉缺血期间左心室壁厚度局部心肌性能超声心动图测量的影响
DOI：
10.1161/01.cir.59.5.926
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发表时间：
1979
期刊：
影响因子：
37.8
通讯作者：
W. Hood
中科院分区：
文献类型：
--
作者：
R. R. Komer;A. Edalji;W. Hood
通过超声心动图技术评估硝酸甘油对局部左心室性能的影响，在急性心肌缺血期间对麻醉的开胸犬进行研究。在左冠状动脉前降支短暂闭塞期间，中央缺血区的舒张末期变薄，而收缩期增厚明显减少。边境地区也出现了类似的但程度较轻的变化。正常区域不受影响。缺血期间以 2.5-50 μg/kg/min 的剂量输注硝酸甘油可降低左心室舒张末压，但不会改变收缩期壁增厚的异常情况。 20 和 50 μ ag/kg 硝酸甘油的推注效果相似，尽管这也会降低主动脉压。在输注硝酸甘油不伴有心动过速的动物亚组中，也没有证据表明缺血性功能障碍发生改变。我们的结论是，硝酸甘油不能改善急性缺血犬心肌的局部心肌性能。预载的降低可能完全是由于药物的外周效应所致。
The effects of nitroglycerin on regional left ventricularperformance, assessed by echocardiographic techniques, were investigated in anesthetized, open-chest dogs during acute myocardial ischemia. During transient occlusion of the left anterior descending coronary artery, there was end-diastolic thinning marked reduction in systolic thickening in the central ischemic zone. Similar changes of lesser degree were noted in the border zone. The normal zone was unaffected. Infusion of nitroglycerin during ischemia in dosages of 2.5–50 μg/kg/min reduced left ventricular end-diastolic pressure withoutchanging the abnormalities of systolic wall thickening. Effects of bolus injections of 20 and 50 μ ag/kg of nitroglycerin were similar, although this also lowered aortic pressure. In a subgroup of animals in which nitroglycerin infusion was unaccompanied by tachycardia, there was also no evidence that ischemic dysfunction was altered. We conclude that nitroglycerin does not improve regional myocardial performance in acutely ischemic canine myocardium. The decrease in preload is probably entirely due to the peripheral effects of the agent.