An IARC evaluation of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans as risk factors in human carcinogenesis.
An IARC evaluation of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans as risk factors in human carcinogenesis.
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DOI：
10.1289/ehp.98106755
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发表时间：
1998-04
影响因子：
10.4
通讯作者：
Rice JM
中科院分区：
文献类型：
--
作者：
McGregor DB;Partensky C;Wilbourn J;Rice JM
1997 年 2 月，国际癌症研究机构 (IARC) 专着项目重新评估了多氯二苯并-对-二恶英，并评估了多氯二苯并呋喃对人类可能的致癌危害，其中使用了暴露人群的最新流行病学数据、实验动物的实验致癌性生物测定以及相关致癌机制的支持证据。 2,3,7,8-四氯二苯并-对-二恶英 (TCDD) 被评估为对人类致癌（IARC 第 1 组分类），依据是对工业事故中严重接触的工人的跟踪得出的对人类致癌性的有限证据以及对实验动物的充分致癌性证据。评估还考虑了以下支持证据： TCDD 是一种实验动物多部位致癌物，多项证据表明其通过涉及芳基碳氢化合物受体的机制发挥作用；这种受体在进化意义上高度保守，在人类和实验动物中的功能相同；在严重暴露的人群中，TCDD 的组织浓度相似，在这些人群中观察到整体癌症风险增加，并且在致癌性测试中出现肿瘤的暴露大鼠中。其他多氯二苯并-对-二恶英、非氯化二苯并-对-二恶英和多氯二苯并呋喃的人类致癌性被评估为不可分类（第3组）。
The International Agency for Research on Cancer (IARC) Monographs program reevaluated polychlorinated dibenzo-p-dioxins and evaluated polychlorinated dibenzofurans as possible carcinogenic hazards to humans in February 1997, using the most recent epidemiologic data on exposed human populations, experimental carcinogenicity bioassays in laboratory animals, and supporting evidence on relevant mechanisms of carcinogenesis. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) was evaluated as carcinogenic to humans (IARC group 1 classification) on the basis of limited evidence of carcinogenicity to humans derived from follow-up of workers who had been heavily exposed in industrial accidents and sufficient evidence of carcinogenicity in experimental animals. The evaluation also considered the following supporting evidence: TCDD is a multisite carcinogen in experimental animals and has been shown by several lines of evidence to act through a mechanism involving the aryl hydrocarbon receptor; this receptor is highly conserved in an evolutionary sense and functions the same way in humans as in experimental animals; tissue concentrations of TCDD are similar in heavily exposed human populations in which an increased overall cancer risk was observed and in exposed rats that developed tumors in carcinogenicity tests. Other polychlorinated dibenzo-p-dioxins, the nonchlorinated dibenzo-p-dioxin, and polychlorinated dibenzofurans were evaluated as not classifiable as to their carcinogenicity to humans (group 3).