Inactivation of Pten in osteo-chondroprogenitor cells leads to epiphyseal growth plate abnormalities and skeletal overgrowth
Inactivation of Pten in osteo-chondroprogenitor cells leads to epiphyseal growth plate abnormalities and skeletal overgrowth
复制标题
DOI：
10.1359/jbmr.070420
复制
发表时间：
2007-08-01
影响因子：
6.2
通讯作者：
Jirik, Frank Robert
中科院分区：
文献类型：
--
作者：
Ford-Hutchinson, Alice Fiona;Ali, Zenobia;Jirik, Frank Robert
为了研究Pten肿瘤抑制因子在骨骼形成中的作用，我们培养了骨-软骨祖细胞中缺乏这种关键磷脂酰肌醇3'-激酶途径调节因子的小鼠。观察到生长板功能障碍和骨骼过度生长的表型。
To study the role of the Pten tumor suppressor in skeletogenesis, we generated mice lacking this key phosphatidylinositol 3'-kinase pathway regulator in their osteo-chondroprogenitors. A phenotype of growth plate dysfunction and skeletal overgrowth was observed.