Apoptotic Cell-Inspired Polymeric Particles for Controlling Microglial Inflammation toward Neurodegenerative Disease Treatment
Apoptotic Cell-Inspired Polymeric Particles for Controlling Microglial Inflammation toward Neurodegenerative Disease Treatment
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凋亡细胞启发的聚合物颗粒用于控制小胶质细胞炎症以治疗神经退行性疾病
DOI：
10.1021/acsbiomaterials.8b01510
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发表时间：
2019
影响因子：
5.8
通讯作者：
Ebara Mitsuhiro
中科院分区：
文献类型：
--
作者：
Nakagawa Yasuhiro;Yano Yuto;Lee Jeonggyu;Anraku Yasutaka;Nakakido Makoto;Tsumoto Kouhei;Cabral Horacio;Ebara Mitsuhiro
已知凋亡细胞通过呈递磷脂酰丝氨酸来抑制大脑中的小胶质细胞炎症。在这项研究中，我们新设计了聚合物颗粒，暴露磷脂酰丝氨酸的抗炎位点，作为凋亡细胞模拟抗炎平台。制备的抗炎颗粒没有表现出细胞毒性，并且显着抑制小胶质细胞系MG6中针对脂多糖刺激的炎症细胞因子白细胞介素6的产生。这种新型聚合物颗粒有潜力建立一种针对脑内炎症的“无细胞”凋亡细胞模拟治疗方法。
Apoptotic cells are known to suppress microglial inflammation in the brain by presenting phosphatidylserine. In this study, we newly designed polymeric particles that expose the anti-inflammatory site of phosphatidylserine to serve as an apoptotic cell-mimetic anti-inflammatory platform. The prepared anti-inflammatory particles showed no cytotoxicity and significantly inhibited the production of the inflammatory cytokine interleukin-6 against lipopolysaccharide stimulation in the microglia cell line MG6. This novel polymeric particle has potential for establishing a “cell-free” apoptotic cell-mimetic treatment for intracerebral inflammation.