Elevated cerebrospinal fluid and serum YKL-40 levels are not associated with symptomatic vasospasm in patients with aneurysmal subarachnoid haemorrhage
Elevated cerebrospinal fluid and serum YKL-40 levels are not associated with symptomatic vasospasm in patients with aneurysmal subarachnoid haemorrhage
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DOI：
10.1016/j.jocn.2006.11.014
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发表时间：
2008-09-01
影响因子：
2
通讯作者：
Kaynar, Mehmet Yasar
中科院分区：
文献类型：
--
作者：
Kacira, Tibet;Hanimoglu, Hakan;Kaynar, Mehmet Yasar
YKL-40是一种新发现的基质蛋白，被认为是在炎症的急性阶段释放。最近有人推测，YKL-40可作为组织炎症部位中性粒细胞功能的特异性血清学标志物。我们的目的是确定22例蛛网膜下腔出血患者脑脊液和血清中YKL-40的水平是否与血管痉挛或预后相关。并与16例脑积水对照组进行比较。我们发现，蛛网膜下腔出血患者的脑脊液和血清中YKL-40水平均显著高于对照组。然而，升高的YKL-40水平与症状性血管痉挛或6个月结局无关。我们发现YKL-40水平升高与蛛网膜下腔出血的严重程度无关，不能作为动脉瘤破裂患者炎症的血清学标志物。(C)2007爱思唯尔有限公司保留所有权利。
YKL-40 is a newly discovered matrix protein that is thought to be released during the acute stages of inflammation. It has recently been speculated that YKL-40 may serve as a specific serological marker of neutrophil function at the site of tissue inflammation. Our aim was to determine whether the levels of YKL-40 in both the cerebrospinal fluid and sera of 22 patients with aneurysmal subarachnoid haemorrhage were associated with either vasospasm or outcome. The levels were also compared with those of 16 control patients with hydrocephalus. We found that patients with aneurysmal subarachnoid haemorrhage had significantly higher YKL-40 levels in both cerebrospinal fluid and serum than controls. However, elevated YKL-40 levels were not associated with symptomatic vasospasm or 6-month outcome. We show that elevated YKL-40 levels are not correlated with the severity of subarachnoid haemorrhage and cannot be used as a serological marker of inflammation in patients with an aneurysm rupture. (C) 2007 Elsevier Ltd. All rights reserved.