A LETHAL ALLELE OF DILUTE IN THE HOUSE MOUSE
A LETHAL ALLELE OF DILUTE IN THE HOUSE MOUSE
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DOI：
10.1038/hdy.1952.48
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发表时间：
1952-01-01
期刊：
影响因子：
3.8
通讯作者：
SEARLE, AG
中科院分区：
文献类型：
--
作者：
SEARLE, AG
小鼠突变体“稀释致死”（符号dl）在菌株C57BL/Gr中自发产生，是马耳他稀释（d）的等位基因。它会导致皮毛稀释并伴有色素颗粒结块，如d，还会引起角弓反张和共济失调的阵挛性惊厥。这些神经系统症状在大约 9 天时出现，并在断奶后不久导致死亡（可能因饥饿）。出生体重正常，但生长速度从 10 天左右开始下降。大脑或内耳没有发现明显的缺陷。 d/dl 小鼠在表型上与 d/d 相同。
The mouse mutant "dilute lethal" (symbol dl) arose spontaneously in strain C57BL/Gr and is an allele of Maltese dilution (d). It causes dilution of fur with clumping of pigment granules, like d, also clonic convulsions with opisthotonus and ataxia. These neurological symptoms appear at about 9 days and lead to death (probably from starvation) soon after weaning. Birth-weight is normal but growth falls off from about 10 days on. No gross defects were found in the brain or inner ear. d/dl Mice are phenotypically identical with d/d.