Serum IGF-I Levels Correlate to Improvement of Functional Outcome after Ischemic Stroke
Serum IGF-I Levels Correlate to Improvement of Functional Outcome after Ischemic Stroke
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DOI：
10.1210/jc.2010-2802
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发表时间：
2011-07-01
影响因子：
5.8
通讯作者：
Aberg, N. David
中科院分区：
文献类型：
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作者：
Aberg, Daniel;Jood, Katarina;Aberg, N. David
背景和目的：GH对GH-IGF-I缺陷患者有积极的认知作用。GH和IGF-I对实验性卒中具有神经保护和再生作用。探讨血清内源性胰岛素样生长因子-I(S-胰岛素样生长因子-I)水平与缺血性卒中患者功能独立性恢复的相关性。对象和方法：对40 7例(男2 6 0例，女14 7例)缺血性卒中患者和随机选择的40例对照组进行血清S-胰岛素样生长因子-I水平的测定。分别于卒中后1~10d(中位数，4d)和卒中后3个月采集血清标本。结果：老年患者急性期血清S胰岛素样生长因子-I水平高于发病后3个月，与对照组比较差异有统计学意义(P<0.001)，老年患者血清胰岛素样生长因子-I水平呈进行性降低。脑卒中患者急性期及3个月后血清S-胰岛素样生长因子-I水平均与3~24个月改良朗金量表评分的改善呈正相关(P=0.001；r=0.174；P<；0.001；r=0.24)。结论：脑卒中康复期血清S-胰岛素样生长因子-I水平升高与远期功能恢复良好相关。(J临床内分泌Metab 96：E1055-E1064,2011)
Context and Objective: GH has positive cognitive effects when given to GH-IGF-I-deficient patients. GH and IGF-I exert both neuroprotective and regenerative effects on experimental stroke. We investigated whether the endogenous serum IGF-I (s-IGF-I) levels correlated with recovery of functional independence in patients who had suffered an ischemic stroke.Subjects and Methods: The s-IGF-I levels were measured in 407 patients (260 males, 147 females) with mean age of 55 (range, 18-69) yr and 40 randomly selected matched controls who were previously included in the Sahlgrenska Academy Study on Ischemic Stroke. Serum samples were collected on two occasions: acutely at 1-10 d (median, 4 d) after stroke and 3 months after the stroke. Recovery after ischemic stroke was evaluated using the modified Rankin scale 3 and 24 months after the stroke, and the Scandinavian Stroke Scale was used for assessments during the acute stage and 3 months after the stroke.Results: The s-IGF-I levels were higher in the acute stage than after 3 months and compared with the controls (P < 0.001 and P < 0.01, respectively), and the s-IGF-I levels were progressively lower in the elderly patients. The levels of s-IGF-I in the acute phase and after 3 months both positively correlated with improvement in the modified Rankin scale scores between 3 and 24 months (P = 0.001; r = 0.174, and P < 0.001; r = 0.24, respectively).Conclusion: A high s-IGF-I during the rehabilitation phase of stroke correlates to better recovery of long-term function. (J Clin Endocrinol Metab 96: E1055-E1064, 2011)