The role of the pre-supplementary motor area in the control of action.

The role of the pre-supplementary motor area in the control of action.
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DOI:
10.1016/j.neuroimage.2007.03.034
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发表时间:
2007
期刊:
影响因子:
5.7
通讯作者:
Kennard C
Kennard C
中科院分区:
医学1区
文献类型:
--
作者:
Nachev P;Wydell H;O'neill K;Husain M;Kennard C

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虽然已知内侧额叶皮质的区域在自主运动时活跃,但它们的确切作用尚不清楚。在这里,我们将功能成像定位与心理物理学相结合,以证明在一例罕见病变涉及右侧补充前运动区(Pre-SMA)但保留辅助运动区(SMA)的患者中,抑制正在进行的运动计划的能力存在显著的选择性对比性损害。我们在简单的反应时间中没有发现相应的延迟,并且表明抑制赤字对反应之间的竞争的存在是敏感的。研究结果表明,在应对冲突的情况下,SMA前在对自愿行动实施控制方面发挥了关键作用。我们在SMA前功能的统一框架下讨论了这些发现,并探索了该地区的现有数据在多大程度上可以仅由这一功能来解释。
Although regions within the medial frontal cortex are known to be active during voluntary movements their precise role remains unclear. Here we combine functional imaging localisation with psychophysics to demonstrate a strikingly selective contralesional impairment in the ability to inhibit ongoing movement plans in a patient with a rare lesion involving the right pre-supplementary motor area (pre-SMA), but sparing the supplementary motor area (SMA). We find no corresponding delay in simple reaction times, and show that the inhibitory deficit is sensitive to the presence of competition between responses. The findings demonstrate that the pre-SMA plays a critical role in exerting control over voluntary actions in situations of response conflict. We discuss these findings in the context of a unified framework of pre-SMA function, and explore the degree to which extant data on this region can be explained by this function alone.
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