Early management of severe traumatic brain injury
Early management of severe traumatic brain injury
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DOI：
10.1016/s0140-6736(12)60864-2
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发表时间：
2012-09-22
期刊：
影响因子：
168.9
通讯作者：
Gruen, Russell L.
中科院分区：
文献类型：
--
作者：
Rosenfeld, Jeffrey V.;Maas, Andrew I.;Gruen, Russell L.
严重创伤性脑损伤仍然是全世界的一个主要保健问题。尽管在理解这种损伤的病理生理学方面取得了重大进展，但这还没有导致结果的实质性改善。在本报告中，我们讨论了目前的知识及其局限性、研究创新和临床意义。严重创伤性脑损伤患者预后的改善可能源于药物和其他治疗、神经修复和再生、手术指征和技术的优化以及联合和单独靶向治疗的进展。创伤性脑损伤的扩展分类和研究设计的创新将巩固这些进步。我们乐观地认为，在未来十年内，严重创伤性脑损伤患者的预后将进一步改善。
Severe traumatic brain injury remains a major health-care problem worldwide. Although major progress has been made in understanding of the pathophysiology of this injury, this has not yet led to substantial improvements in outcome. In this report, we address present knowledge and its limitations, research innovations, and clinical implications. Improved outcomes for patients with severe traumatic brain injury could result from progress in pharmacological and other treatments, neural repair and regeneration, optimisation of surgical indications and techniques, and combination and individually targeted treatments. Expanded classification of traumatic brain injury and innovations in research design will underpin these advances. We are optimistic that further gains in outcome for patients with severe traumatic brain injury will be achieved in the next decade.