Pathophysiology of sepsis-induced myocardial dysfunction.
Pathophysiology of sepsis-induced myocardial dysfunction.
复制标题
脓毒症引起的心肌功能障碍的病理生理学
DOI：
10.1186/s40779-016-0099-9
复制
发表时间：
2016
影响因子：
21.1
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Lv X;Wang H
脓毒症引起的心肌功能障碍是脓毒症患者的常见并发症，与死亡率增加有关。在临床背景下，人们曾经认为，心肌功能障碍不是脓毒症患者的主要病理过程，至少部分原因是缺乏合适的临床标志物来评估脓毒症期间的内在心肌功能。虽然脓毒症引起的心肌功能障碍已经在临床和基础研究中研究了30多年，但其病理生理学尚未完全了解，并且不存在针对这种疾病的特异性治疗。本文就脓毒症引起的心肌功能不全的发病机制和临床特点作一综述。
Sepsis-induced myocardial dysfunction is a common complication in septic patients and is associated with increased mortality. In the clinical setting, it was once believed that myocardial dysfunction was not a major pathological process in the septic patients, at least in part, due to the unavailability of suitable clinical markers to assess intrinsic myocardial function during sepsis. Although sepsis-induced myocardial dysfunction has been studied in clinical and basic research for more than 30 years, its pathophysiology is not completely understood, and no specific therapies for this disorder exist. The purpose of this review is to summarize our current knowledge of sepsis-induced myocardial dysfunction with a special focus on pathogenesis and clinical characteristics.