HEMOGLOBIN LEVELS IN A HIMALAYAN HIGH-ALTITUDE POPULATION
HEMOGLOBIN LEVELS IN A HIMALAYAN HIGH-ALTITUDE POPULATION
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DOI：
10.1002/ajpa.1330630306
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发表时间：
1984-01-01
影响因子：
2.8
通讯作者：
REICHSMAN, AB
中科院分区：
文献类型：
--
作者：
BEALL, CM;REICHSMAN, AB
本报告提供了喜马拉雅高海拔地区原住民样本中血红蛋白浓度的数据，这些数据是在他们习惯居住的海拔高度测量的。在尼泊尔上丘米克海拔 3250-3560 m 的 270 名健康藏族成年人的样本中，平均 Hb 浓度为 16.1 .+-。成年男性 1.2 gm/dl，14.4 .+-。绝经前为 1.4 gm/dl，绝经前为 15.0 .+-。绝经后成年女性中为 1.1 gm/dl。 126 名男性中的 123 名 (98%)、100 名绝经前女性中的 96 名 (96%) 和 44 名绝经后女性中的 36 名 (82%) 的 Hb 浓度在海平面平均值的 2 个标准差以内。健康人群可能生活在高海拔地区，但其血红蛋白的升高程度却没有安第斯高地人广为人知和引用的水平。比较已发表的关于位于 3200 m 至 4100 m 之间的成人喜马拉雅和安第斯样本的平均 Hb 浓度的数据表明，喜马拉雅的平均值系统性较低。这可能解释了所报告的慢性高山病（蒙日氏病）患病率的人群差异。喜马拉雅山和安第斯高地人可能代表了高海拔血液适应的另一种模式。
This report presents data on Hb concentrations in a sample of Himalayan high altitude natives, measured at their habitual altitude of residence. In this sample of 270 healthy Tibetan adults resident at 3250-3560 m in Upper Chumik, Nepal, the mean Hb concentration is 16.1 .+-. 1.2 gm/dl among adult males, 14.4 .+-. 1.4 gm/dl among premenopausal and 15.0 .+-. 1.1 gm/dl among postmenopausal adult females. 123 of 126 (98%) males, 96 of 100 (96%) premenopausal and 36 of 44 (82%) postmenopausal females have Hb concentrations within 2 standard deviations of the sea level mean. A healthy population may reside at high altitude without the degree of elevation in Hb widely known and cited for Andean highlanders. Comparing published data on mean Hb concentrations of adult Himalayan and Andean samples residing between 3200 m and 4100 m reveals that Himalayan means are systematically lower. This is turn may account for the reported population differences in the prevalence of chronic mountain sickness (Monge''s disease). Himalayan and Andean highlanders may represent alternative patterns of high altitude hematological adaptation.