Spiroplasma as a candidate agent for the transmissible spongiform encephalopathies.
Spiroplasma as a candidate agent for the transmissible spongiform encephalopathies.
复制标题
螺原体作为传染性海绵状脑病的候选药物。
DOI：
10.1097/01.jnen.0000183553.01458.87
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发表时间：
2005
影响因子：
3.2
通讯作者：
Bastian,FrankO
中科院分区：
文献类型：
--
作者：
Bastian,FrankO
一株新螺旋体的回收。从患有瘙痒病的绵羊、患有慢性萎缩性脑病的宫颈以及从克雅氏病患者通过胚胎获得的脑组织中，提出了螺旋体在传染性海绵状脑病(TSE)中所起作用的问题。在这篇综述中，我们在流行病学感染模型中加入了过去30年积累的证据，表明螺旋体感染参与了TSE。这些数据支持我们的假设，即螺旋体。是TSE的原因，尽管必须满足科赫的假设才能明确回答这个问题。
The recovery of a novelSpiroplasma sp. from brain tissues from sheep with scrapie, cervids with chronic wasting disease, and from patients with Creutzfeldt-Jakob disease through passage through embryonated eggs has raised the issue of the role of Spiroplasma in the transmissible spongiform encephalopathies (TSE). In this review, we have inserted into an epidemiologic infection model evidence accumulated over the past 30 years showing involvement of Spiroplasma infection in TSE. These data support our hypothesis that aSpiroplasma sp. is the causal agent of TSE, although Koch's postulates must be fulfilled to definitively answer that question.