Current status of superficial pharyngeal squamous cell carcinoma in Japan
Current status of superficial pharyngeal squamous cell carcinoma in Japan
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DOI：
10.1007/s10147-017-1135-9
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发表时间：
2017-10-01
影响因子：
3.3
通讯作者：
Higashi, Takahiro
中科院分区：
文献类型：
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作者：
Rikitake, Ryoko;Ando, Mizuo;Higashi, Takahiro
为了了解日本浅表咽鳞状细胞癌的现状和治疗方法，我们分析了2011至2013年间所有确诊的病例，这些病例记录在以医院为基础的全国癌症登记数据库中。我们提取了关于患者性别、年龄、肿瘤部位、组织学、呈现途径、初始治疗和TNM分期的数据。此外，我们比较了咽癌和食道癌的特征。共有来自409个机构的16,521例口咽癌和下咽癌纳入研究。Tis肿瘤的诊断很少见，两种肿瘤都可能在晚期被诊断(n=866，5.3%)。在其他疾病的随访检查中，最常发现的疾病是TIS(n=608，70%)。虽然口咽部TIS患者中男性多于T1-4患者(分别为88%和82%)，但下咽癌患者中男性所占比例也同样高(分别为94%和92%)。口咽Tis肿瘤最常见的部位是后壁(32%)，而T1-4肿瘤最常见的是侧壁(36%)。在下咽癌中，Tis和T1-4均位于梨状窝最常见(62%)。在各个机构确诊的TIS肿瘤的比例与接受内窥镜治疗的次数(r=0.32，P<；0.001)和食道癌病例数(r=0.37，P<；0.001)呈正相关。我们的国家数据库研究阐明了日本浅表咽鳞状细胞癌患者目前的特点。在早期诊断和标准化治疗方面有必要进一步改进。
To investigate the status and treatment of superficial pharyngeal squamous cell carcinoma in Japan.We analyzed all cases diagnosed between 2011 and 2013, as recorded in the national database of hospital-based cancer registries. We extracted data on patient sex, age, tumor locations, histology, presentation routes, initial treatments, and TNM stages. Additionally, we compared the characteristics of pharyngeal carcinoma to those of esophageal cancer.A total of 16,521 oropharyngeal and hypopharyngeal cancers from 409 institutions were included. Diagnosis of Tis tumors was infrequent, and both cancers were likely to be diagnosed at an advanced stage (n = 866, 5.3%). Tis diseases were the most commonly detected during follow-up examinations for other diseases (n = 608, 70%). While more oropharyngeal Tis patients were men compared to T1-4 patients (88 vs 82%, respectively), hypopharyngeal cancer patients comprised an equally high proportion of men (94 vs 92%, respectively). The most common location of oropharyngeal Tis tumors was the posterior wall (32%), whereas T1-4 tumors were most commonly found on the lateral wall (36%). In hypopharyngeal cancer, both Tis and T1-4 were most commonly located in the pyriform sinus (62%). The proportion of Tis tumors diagnosed at individual institutions showed a positive correlation with the number of endoscopic treatments (r = 0.32, P < 0.001) and the number of esophageal cancer cases (r = 0.37, P < 0.001).Our national database study elucidated the current characteristics of superficial pharyngeal squamous cell carcinoma patients in Japan. Further improvements in early diagnosis and standardized treatments are warranted.