The Hippo Signaling Pathway in the Regulation of Skeletal Muscle Mass and Function.
The Hippo Signaling Pathway in the Regulation of Skeletal Muscle Mass and Function.
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DOI：
10.1249/jes.0000000000000142
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发表时间：
2018-04
影响因子：
5.7
通讯作者：
Gregorevic P
中科院分区：
文献类型：
--
作者：
Watt KI;Goodman CA;Hornberger TA;Gregorevic P
The Hippo signaling pathway regulates the activity of the proteins Yes-associated protein (Yap) and transcriptional co-activator with PDZ-binding motif (Taz) to control tissue growth in many different cell types. Previously, we demonstrated Yap is a critical regulator of skeletal muscle mass. We hypothesize that alterations in Yap and Taz activity modulate the anabolic adaptations of skeletal muscle to resistance exercise. Yes-associated protein (Yap) and transcriptional co-activator with PDZ-binding motif (Taz) may modulate resistance exercise-induced skeletal muscle hypertrophy.
