MODIFICATIONS OF CALLENDER CLASSIFICATION OF UVEAL MELANOMA AT THE "ARMED-FORCES-INSTITUTE-OF-PATHOLOGY
MODIFICATIONS OF CALLENDER CLASSIFICATION OF UVEAL MELANOMA AT THE "ARMED-FORCES-INSTITUTE-OF-PATHOLOGY
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DOI：
10.1016/s0002-9394(14)77914-0
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发表时间：
1983-01-01
影响因子：
4.2
通讯作者：
GAMEL, JW
中科院分区：
文献类型：
--
作者：
MCLEAN, IW;FOSTER, WD;GAMEL, JW
回顾了1970年以前在美国武装部队病理学研究所登记的葡萄膜黑色素瘤病例（100例），并对其进行了重新分类，以确定Callender分类的变化。将新的分类与原始分类进行比较，以确定这些变化对眼球摘除术后患者结局预测的影响。病理学家最初将100例病例中的52例归类为梭形细胞型黑素瘤。100例中只有31例被重新分类为梭形细胞型（2例梭形细胞痣和29例梭形细胞黑色素瘤）。根据上皮样细胞的百分比和大小，将分类为混合细胞型的肿瘤进一步细分为各组。以前分类为梭形细胞型的肿瘤，含有小或罕见的上皮样细胞，重新分类为混合细胞型。这改善了对患者结局的预测。核仁大小和多形性是葡萄膜黑色素瘤分型时应考虑的重要变量。
Well-documented cases (100) of uveal melanoma accessioned at the Armed Forces Institute of Pathology [USA] before 1970 were reviewed and reclassified to identify changes made in the Callender classification. The new classification was compared with the original classification to determine the effect of the changes on the prediction of outcome for the patient after enucleation. Staff pathologists had originally classified 52 of the 100 cases as spindle-cell type melanoma. Only 31 of the 100 cases were reclassified as spindle-cell types (2 spindle-cell nevi and 29 spindle-cell melanomas). Tumors classified as mixed-cell type were further subdivided into groups based on the percentage and size of the epithelioid cells. Tumors formerly classified as spindle-cell type that contained small or rare epithelioid cells were reclassified as mixed-cell type. This improved the prediction of outcome for the patient. Nucleolar size and pleomorphism were important variables that should be considered in the classification of uveal melanomas.