Fabrication and characterization of poly(N-isopropyl acrylamide)-gold nanoshell structures.
Fabrication and characterization of poly(N-isopropyl acrylamide)-gold nanoshell structures.
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DOI：
10.1166/jnn.2010.2540
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发表时间：
2010-10
影响因子：
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通讯作者：
Caiyun Jiang;Hui Li;Xueping Jia;Xiaoyuan Ma;Yong Qian;Weiping Qian
中科院分区：
文献类型：
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作者：
Caiyun Jiang;Hui Li;Xueping Jia;Xiaoyuan Ma;Yong Qian;Weiping Qian
提出了一种新型的核壳结构，即以聚N-异丙基丙烯酰胺（PNIPAM）微球为核，金为壳。这些结构的制造是方便的，因为省略了对PNIPAM或金纳米颗粒（GNP）的修饰。通过静电吸附法将纳米金颗粒附着在PNIPAM微球表面，通过调节HAuCl 4溶液的pH值来控制纳米金颗粒的生长速率，使纳米金颗粒作为种子快速生长成完整的壳层。这些结构联合收割机结合了PNIPAM微球的温敏特性和GNS的光学特性，并且可以通过调节PNIPAM微球的温度来改变GNS的局域表面等离子体共振（LSPR），使其具有良好的药物释放前景。它们在牛血清白蛋白（BSA）中具有良好的生物稳定性，并且在700 nm附近具有LSPR，有望用于光学生物传感器和全血光学分析。
Novel core-shell structures were presented here which consist of Poly(N-isopropyl acrylamide) (PNIPAM) microspheres as cores and gold as shells. The fabrication of these structures was convenient because the modifications to PNIPAM or gold nanoparticles (GNPs) were omitted. GNPs were attached to the surface of PNIPAM microspheres by means of electrostatic adsorption, and then acted as seeds to grow quickly into complete shells by optimizing the pH of the HAuCl4 solution to control the growth rate of gold nanoshells (GNSs). These structures combine the thermo-responsive behavior of PNIPAM microspheres with optical property of GNSs, and the localized surface plasmon resonance (LSPR) of the GNSs can be changed by adjusting the temperature of the PNIPAM microspheres which make them have great prospects for drug release. Their good biological stability in bovine serum albumin (BSA) and the LSPR located near 700 nm are expected for optical biosensors and optical analysis of whole-blood.