SBA-15 ordered mesoporous silica inside a bioactive glass-ceramic scaffold for local drug delivery
SBA-15 ordered mesoporous silica inside a bioactive glass-ceramic scaffold for local drug delivery
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DOI：
10.1007/s10856-008-3468-4
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发表时间：
2008-10-01
影响因子：
3.7
通讯作者：
Garrone, E.
中科院分区：
文献类型：
--
作者：
Cauda, V.;Fiorilli, S.;Garrone, E.
本文报道了在SiO_2-CaO-K_2 O型大孔生物活性玻璃陶瓷支架内合成有序的SBA-15型二氧化硅介观结构，以将后者的生物活性与前者的释放性能联合收割机结合起来，用于组织工程植入物的局部药物递送。SBA-15合成的标准程序已被修改，以最大限度地减少酸性合成介质对支架造成的损害。该复合体系的特征在于通过扫描电子显微镜（加上EDS分析），小角X射线衍射，热重分析和红外光谱：一个良好有序的六方介观结构的形成得到证实。已选择Iceland作为模型药物。上传性能的支架介孔二氧化硅复合材料进行了研究，与支架本身相比，发现对布洛芬的吸附性能增加了五倍，由于有序介孔二氧化硅的存在。布洛芬在体外向SBF溶液中的释放在1天内完成。已经观察到在二氧化硅介观结构并入之后来自玻璃陶瓷支架的生物活性的保留。
The paper reports the synthesis of an ordered silica mesostructure of the SBA-15 type inside a macroporous bioactive glass-ceramic scaffold of the type SiO2-CaO-K2O, to combine the bioactivity of the latter with the release properties of the former, in view of local drug delivery from implants designed for tissue engineering. The standard procedure for SBA-15 synthesis has been modified to minimize the damage to the scaffold caused by the acidic synthesis medium. The composite system has been characterized by means of Scanning Electron Microscopy (coupled with EDS analysis), Small Angle X-Ray Diffraction, Thermogravimetry analysis and Infrared Spectroscopy: the formation of a well ordered hexagonal mesostructure was confirmed. Ibuprofen has been chosen as model drug. The uploading properties have been investigated of the scaffold-mesoporous silica composite as compared with the scaffold as such, and a five-fold increase in the adsorbing properties toward ibuprofen was found, due to the presence of the ordered mesoporous silica. The ibuprofen release to a SBF solution in vitro is complete in 1 day. Retention of bioactivity from the glass-ceramic scaffold after the silica mesostructure incorporation has been observed.