Using retinal architecture to help characterize multiple sclerosis patients
Using retinal architecture to help characterize multiple sclerosis patients
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DOI：
10.3129/i10-063
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发表时间：
2010-10-01
影响因子：
4.2
通讯作者：
Freedman, Mark S.
中科院分区：
文献类型：
--
作者：
Costello, Fiona;Hodge, William;Freedman, Mark S.
目的：我们比较了异质性多发性硬化（MS）队列中的视网膜神经纤维层（RNFL）厚度和视觉功能，以确定光学相干断层扫描（OCT）是否可以补充用于表征MS患者的现有方法。设计：横断面队列研究。193例视神经炎（ON）患者为临床孤立综合征（CIS）（n = 63），复发缓解型MS（RRMS）（n = 108），继发性进行性MS（SPMS）（n = 13）和原发性进行性MS（PPMS）（n = 9）。方法：所有患者在一个学术机构接受标准化的眼科、神经学和OCT测试。RNFL值在PPMS（94.3 μ m）、RRMS（99.6 μ m）和SPMS（84.7 μ m）中相对于CIS眼（105.7 μ m）降低（p < 0.0001）。复发性ON眼的RNFL值（64.2 μ m）低于受单一ON事件影响的眼（86.3 μ m）（p < 0.0001）。RRMS患者RNFL厚度与神经功能障碍之间的相关性最强（r =-0.51，p < 0.0001）。RNFL厚度与CIS（r = 0.23，p < 0.01）和RRMS（r = 0.22，p < 0.01）患者的视野敏感度相关。简单线性回归显示，RNFL值小于75 μ m时，RNFL每减少10 pm，视野灵敏度降低5.8分贝（校正R（2）= 0.35，p < 0.0001）。结论：RNFL厚度与视功能之间存在强相关性，特别是在ON眼中。OCT可以补充用于表征MS患者的现有工具，但需要进一步研究。
Objective: We compared retinal nerve fibre layer (RNFL) thickness and visual function in a heterogeneous multiple sclerosis (MS) cohort to determine whether optical coherence tomography (OCT) may complement the existing methods used to characterize MS patients.Design: Cross-sectional cohort study.Participants: One hundred and ninety-three patients with optic neuritis (ON) as a clinically isolated syndrome (CIS) (n = 63), relapsing-remitting MS (RRMS) (n = 108), secondary progressive MS (SPMS) (n = 13), and primary progressive MS (PPMS) (n = 9).Methods: All patients underwent standardized ophthalmic, neurological, and OCT testing at a single academic institution.Results: RNFL values were reduced in PPMS (94.3 mu m), RRMS (99.6 mu m), and SPMS eyes (84.7 mu m) relative to CIS eyes (105.7 mu m) (p < 0.0001). RNFL values were lower in eyes with recurrent ON (64.2 mu m) relative to eyes affected by a single ON event (86.3 mu m) (p < 0.0001). The strongest correlation between RNFL thickness and neurological disability occurred in RRMS patients (r = -0.51, p < 0.0001). RNFL thickness correlated with visual field sensitivity for CIS (r = 0.23, p < 0.01) and RRMS (r = 0.22, p < 0.01) patients. Simple linear regression showed that every 10 pm decrease in RNFL correlated with a 5.8 decibel decrease in visual field sensitivity (adjusted R(2) = 0.35, p < 0.0001) for RNFL values less than 75 mu m.Conclusions: There were robust correlations between RNFL thickness and visual function, particularly in ON eyes. OCT may complement the existing tools used to characterize MS patients, but further studies are needed.