The Microbiota: A New Variable Impacting Cancer Treatment Outcomes.

The Microbiota: A New Variable Impacting Cancer Treatment Outcomes.
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DOI:
10.1158/1078-0432.ccr-17-0864
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发表时间:
2017-07-01
期刊:
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子:
--
通讯作者:
Gajewski TF
Gajewski TF
中科院分区:
其他
文献类型:
--
作者:
Fessler JL;Gajewski TF

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临床前证据已经确定,宿主肠道微生物群可以促进癌症模型中的治疗反应,这一发现得到了早期临床数据的支持。微生物组与肿瘤学临床结果之间的这种联系是抗生素管理和微生物群调节干预以改善结果的新考虑的原因。
Preclinical evidence has established that the host commensal microbiota can contribute to therapeutic response in cancer models, a finding supported by early clinical data. This connection between the microbiome and clinical outcome in oncology is cause for new consideration in the administration of antibiotics and microbiota-modulating interventions to improve outcomes.