Ethosomes and ultradeformable liposomes for transdermal delivery of clotrimazole: A comparative assessment
Ethosomes and ultradeformable liposomes for transdermal delivery of clotrimazole: A comparative assessment
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DOI：
10.1016/j.jsps.2011.10.001
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发表时间：
2012-04-01
影响因子：
4.1
通讯作者：
Jain, Dinesh K.
中科院分区：
文献类型：
--
作者：
Maheshwari, Rahul G. S.;Tekade, Rakesh K.;Jain, Dinesh K.
本工作的目的是制备、评价和比较新型囊泡型纳米载体：含抗真菌生物活性克霉唑(CLT)的醇体和超变形脂质体的透皮潜力。最高包封率分别为68.73+/-1.4%和55.51+/-1.7%，最佳纳米粒径范围分别为132+/-9.5 nm和121+/-9.7 nm，最小多分散指数分别为0.027+/-0.011和0.067+/-0.009。与TT3制剂(50.16+/-3.84mg/cm(2)/h；1.0h)相比，ET4制剂的透皮吸收速率增加56.25+/-5.49mg/cm(2)/h，滞留时间缩短0.9h。皮肤相互作用和FT-IR研究表明，ET4比TT3制剂具有更强的渗透促进作用。ET4制剂对念珠菌的抑制率最高(34.6+/-0.57 mm)，而TT3制剂(29.6+/-0.57 mm)和市售乳膏制剂(19.0+/-1.00 mm)对念珠菌的抑制率最高。结果表明，醇体是克霉唑经皮和透皮给药的最佳载体系统。(C)2011年沙特国王大学。爱思唯尔制作和主持版权所有。
The objective of work was to formulate, evaluate and compare the transdermal potential of novel vesicular nanocarriers: ethosomes and ultradeformable liposomes, containing clotrimazole (CLT), an anti-fungal bioactive. The ethosomal formulation (ET4) and ultradeformable liposomal (UL) formulation (TT3) showed highest entrapment 68.73 +/- 1.4% and 55.51+/- 1.7%, optimal nanometric size range 132 +/- 9.5 nm and 121+/- 9.7 nm, and smallest polydispersity index 0.027 +/- 0.011 and 0.067 +/- 0.009, respectively. The formulation ET4 provided enhanced transdermal flux 56.25 +/- 5.49 mu g/cm(2)/h and decreased the lag time of 0.9 h in comparison to TT3 formulation (50.16 +/- 3.84 mu g/cm(2)/h; 1.0 h). Skin interaction and FT-IR studies revealed greater penetration enhancing effect of ET4 than TT3 formulation. ET4 formulation also had the highest zone of inhibition (34.6 +/- 0.57 mm), in contrast to TT3 formulation (29.6 +/- 0.57 mm) and marketed cream formulation (19.0 +/- 1.00 mm) against candidal species. Results suggested ethosomes to be the most proficient carrier system for dermal and transdermal delivery of clotrimazole. (C) 2011 King Saud University. Production and hosting by Elsevier B. V. All rights reserved.