Early umbilical cord clamping contributes to elevated blood lead levels among infants with higher lead exposure
Early umbilical cord clamping contributes to elevated blood lead levels among infants with higher lead exposure
复制标题
DOI：
10.1016/j.jpeds.2007.04.056
复制
发表时间：
2007-11-01
影响因子：
5.1
通讯作者：
Dewey, Kathryn G.
中科院分区：
文献类型：
--
作者：
Chaparro, Camila M.;Fornes, Raymond;Dewey, Kathryn G.
目的探讨婴儿铁的状态，修改脐带夹紧时间和婴儿喂养模式，影响婴儿血铅浓度在6个月龄。研究设计参与者是一个子集的妇女和他们的婴儿随机接受早期（10秒）或延迟（2分钟）脐带夹紧和监测6个月后在墨西哥城。铁和铅的状态进行了分析，在母亲，胎盘，和6个月的婴儿血液样本。基线母亲铅暴露数据和婴儿喂养数据在2，4。结果在总样本中，母亲血铅浓度、婴儿铁蛋白和母乳喂养方式可预测婴儿血铅浓度。在胎盘血铅浓度较高的婴儿和母乳喂养的婴儿没有接受任何铁强化配方奶粉或牛奶在6个月，早期夹紧增加婴儿血铅浓度，通过降低婴儿铁状态介导的部分效果。结论早期脐带夹紧，通过降低婴儿铁状态，有助于在6个月的高风险婴儿血铅浓度。
Objective To investigate whether infant iron status, modified by umbilical cord clamping time and infant feeding mode, affected infant blood lead concentration at 6 months of age.Study design Participants were a subset of women and their infants randomized to receive early (10 seconds) or delayed (2 minutes) umbilical cord clamping and were monitored to 6 months postpartum in Mexico City. Iron and lead status was analyzed in maternal, placental, and 6-month infant blood samples. Baseline maternal lead exposure data and infant feeding data at 2, 4. and 6 months were collected.Results In the total sample. maternal blood lead concentration, infant ferritin, and breast-feeding practices predicted infant blood lead concentration. Among infants with higher placental blood lead concentration and breast-fed infants not receiving any iron-fortified formula or milk at 6 months, early clamping increased infant blood lead concentration, an effect mediated in part via decreased infant iron status.Conclusions Early cord clamping, by decreasing infant iron status, contributes to higher blood lead concentrations at 6 months of age among infants at high risk.