Chemokine signaling guides regional patterning of the first embryonic artery
Chemokine signaling guides regional patterning of the first embryonic artery
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DOI：
10.1101/gad.1813509
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发表时间：
2009-10-01
影响因子：
10.5
通讯作者：
Lawson, Nathan D.
中科院分区：
文献类型：
--
作者：
Siekmann, Arndt F.;Standley, Clive;Lawson, Nathan D.
主动脉贯穿身体，但对于它在不同解剖位置是如何形成模式的却知之甚少。在此，我们表明主动脉由源自胚胎内不同位置的基因不同的内皮细胞发育而来。此外，趋化因子（C - X - C基序）受体4a（cxcr4a）仅限于源自前中胚层的内皮细胞，并且是侧主动脉形成所特需的。Cxcl12b是一种cxcr4a配体，在侧主动脉下方的内胚层中表达，并且cxcl12b缺失产生与cxcr4a缺陷相同的表型。这些研究揭示了主动脉内意想不到的内皮多样性，这对于通过局部信号促进其区域模式形成是必要的。
The aorta traverses the body, yet little is known about how it is patterned in different anatomical locations. Here, we show that the aorta develops from genetically distinct endothelial cells originating from diverse locations within the embryo. Furthermore, chemokine (C-X-C motif) receptor 4a (cxcr4a) is restricted to endothelial cells derived from anterior mesoderm, and is required specifically for formation of the lateral aortae. Cxcl12b, a cxcr4a ligand, is expressed in endoderm underlying the lateral aortae, and loss of cxcl12b phenocopies cxcr4a deficiency. These studies reveal unexpected endothelial diversity within the aorta that is necessary to facilitate its regional patterning by local cues.