Identification of Incident CKD Stage 3 in Research Studies
Identification of Incident CKD Stage 3 in Research Studies
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DOI：
10.1053/j.ajkd.2014.02.021
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发表时间：
2014-08-01
影响因子：
13.2
通讯作者：
Coresh, Josef
中科院分区：
文献类型：
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作者：
Grams, Morgan E.;Rebholz, Casey M.;Coresh, Josef
背景：在流行病学研究中，新发慢性肾脏病（CKD）通常通过在计划的研究随访时进行的实验室检测来确定。鉴于慢性肾脏病相关的发病率和死亡率，新发疾病患者可能不太可能参加预定的随访，从而影响观察到的相关性。本研究的目的是按慢性肾脏病状态量化失访情况，并确定补充诊断代码数据是否能提高对新发慢性肾脏病的捕捉。
研究设计：前瞻性队列研究。
研究地点和参与者：社区动脉粥样硬化风险（ARIC）研究中的11560名参与者从基线随访（1996 - 1999年）到随访（2011 - 2013年）接受了住院和死亡的持续监测。马里兰州华盛顿县的一部分住院病例用于诊断代码验证（n = 2540）。
预测因素：基线人口统计学特征和合并症情况。
结果：通过随访（基于随访的定义）或住院监测（基于住院的定义）确定的3期新发慢性肾脏病。
测量：基于随访的定义：从基线估计肾小球滤过率下降≥25%至……
Background: In epidemiologic research, incident chronic kidney disease (CKD) commonly is determined by laboratory tests performed at planned study visits. Given the morbidity and mortality associated with CKD, persons with incident disease may be less likely to attend scheduled visits, affecting observed associations. The objective of this study was to quantify loss to follow-up by CKD status and determine whether supplementation with diagnostic code data improves capture of incident CKD.Study Design: Prospective cohort study.Setting & Participants: 11,560 participants in the Atherosclerosis Risk in Communities (ARIC) Study underwent continuous surveillance for hospitalizations and death from baseline visit (1996-1999) to follow-up visit (2011-2013). A subset of hospitalizations in Washington County, MD, was used in diagnostic code validation (n = 2,540).Predictor: Baseline demographics and comorbid conditions.Outcomes: Incident CKD stage 3 ascertained by follow-up visit (visit-based definition) or hospitalization surveillance (hospitalization-based definition).Measurements: Visit-based definition: >= 25% decline from baseline estimated glomerular filtration rate to