A comparison of economic demand and conditioned-cued reinstatement of methamphetamine-seeking or food-seeking in rats.
A comparison of economic demand and conditioned-cued reinstatement of methamphetamine-seeking or food-seeking in rats.
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DOI：
10.1097/fbp.0b013e3283473be4
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发表时间：
2011-08
影响因子：
1.6
通讯作者：
See RE
中科院分区：
文献类型：
--
作者：
Galuska CM;Banna KM;Willse LV;Yahyavi-Firouz-Abadi N;See RE
本研究探讨了继续获得甲基苯丙胺或食品强化是否改变了对两者的经济需求。需求弹性和提示诱导恢复之间的关系也被确定。雄性 Long-Evans 大鼠在食物颗粒或甲基苯丙胺（20 μg/50 μl 输注）的固定比例需求增加的情况下受到杠杆压力。对于两组，在固定比例 3 的时间表下持续使用强化剂（12 天，2 小时）之前和之后获得需求曲线。第三组在食物需求测定期间继续获得甲基苯丙胺，第四组在测定期间戒除甲基苯丙胺。所有组都经历了消退过程，然后进行提示诱导的恢复测试。尽管粮食需求的弹性不如甲基苯丙胺需求，但继续获得甲基苯丙胺使甲基苯丙胺需求曲线向上移动，而粮食需求曲线向下移动。在一些老鼠中，甲基苯丙胺的需求也变得缺乏弹性。继续获得食物对食物需求没有影响。相对于食物而言，继续获取甲基苯丙胺后的恢复率更高。对于甲基苯丙胺，弹性和恢复措施是相关的。我们的结论是，继续获得甲基苯丙胺（而不是食物）会以暗示甲基苯丙胺增强强度的方式改变需求。需求弹性和恢复措施似乎是药物寻求的相关指标。
The present study examined whether continued access to methamphetamine or food reinforcement changed economic demand for both. The relationship between demand elasticity and cue-induced reinstatement was also determined. Male Long-Evans rats lever-pressed under increasing fixed-ratio requirements for either food pellets or methamphetamine (20 μg/50 μl infusion). For two groups, demand curves were obtained before and after continued access (12 days, 2-hr sessions) to the reinforcer under a fixed-ratio 3 schedule. A third group was given continued access to methamphetamine between determinations of food demand and a fourth group abstained from methamphetamine between determinations. All groups underwent extinction sessions, followed by a cue-induced reinstatement test. Although food demand was less elastic than methamphetamine demand, continued access to methamphetamine shifted the methamphetamine demand curve upward and the food demand curve downward. In some rats, methamphetamine demand also became less elastic. Continued access to food had no effect on food demand. Reinstatement was higher after continued access to methamphetamine relative to food. For methamphetamine, elasticity and reinstatement measures were correlated. We conclude that continued access to methamphetamine – but not food – alters demand in ways suggestive of methamphetamine accruing reinforcing strength. Demand elasticity and reinstatement measures appear to be related indices of drug-seeking.